Growth hormone upregulates gastrin and peptide YY gene expression

Guillermo Gomez, Vidyavathi Udupi, Xiang Qi, Felix Lluis, Srinivasan Rajaraman, James C. Thompson, George H. Greeley

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The purpose of these studies was to examine the effects of excess growth hormone (GH) on gastrin and peptide YY (PYY) gene expression. Transgenic mice with the bovine GH gene linked to a mouse metallothionein I promoter were used as a model of chronic GH excess. Antral gastrin mRNA and peptide levels were elevated significantly (P < 0.05) in GH transgenic mice compared with wild type littermates. Ileal PYY mRNA and ileal and colonic PYY levels were significantly elevated in GH transgenic mice compared with wild type littermates. The elevations in gastrin and PYY gene expression in GH transgenic mice were independent of food intake. Serum concentrations of gastrin and PYY were also elevated in GH transgenic mice. Immunohistochemical analysis showed that the density of PYY-containing cells in the colon of GH transgenic mice and wild type littermates did not differ. In addition, the mRNA and protein levels of chromogranin A, a marker of endocrine cells, were not increased in the colon of GH transgenic mice. Together, these data indicate that GH, insulin-like growth factor I, or both can upregulate gastrointestinal gastrin and PYY gene expression directly.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Volume271
Issue number3 34-3
StatePublished - Sep 1996
Externally publishedYes

Fingerprint

Peptide YY
Gastrins
Gene expression
Transgenic Mice
Growth Hormone
Up-Regulation
Gene Expression
Messenger RNA
Colon
Chromogranin A
Endocrine Cells
Metallothionein
Insulin-Like Growth Factor I
Eating
Peptides
Genes
Cells
Serum

Keywords

  • endocrine cells
  • messenger ribonucleic acid
  • neurotensin
  • Northern blotting

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Biochemistry
  • Physiology (medical)

Cite this

Gomez, G., Udupi, V., Qi, X., Lluis, F., Rajaraman, S., Thompson, J. C., & Greeley, G. H. (1996). Growth hormone upregulates gastrin and peptide YY gene expression. American Journal of Physiology - Endocrinology and Metabolism, 271(3 34-3).

Growth hormone upregulates gastrin and peptide YY gene expression. / Gomez, Guillermo; Udupi, Vidyavathi; Qi, Xiang; Lluis, Felix; Rajaraman, Srinivasan; Thompson, James C.; Greeley, George H.

In: American Journal of Physiology - Endocrinology and Metabolism, Vol. 271, No. 3 34-3, 09.1996.

Research output: Contribution to journalArticle

Gomez, G, Udupi, V, Qi, X, Lluis, F, Rajaraman, S, Thompson, JC & Greeley, GH 1996, 'Growth hormone upregulates gastrin and peptide YY gene expression', American Journal of Physiology - Endocrinology and Metabolism, vol. 271, no. 3 34-3.
Gomez G, Udupi V, Qi X, Lluis F, Rajaraman S, Thompson JC et al. Growth hormone upregulates gastrin and peptide YY gene expression. American Journal of Physiology - Endocrinology and Metabolism. 1996 Sep;271(3 34-3).
Gomez, Guillermo ; Udupi, Vidyavathi ; Qi, Xiang ; Lluis, Felix ; Rajaraman, Srinivasan ; Thompson, James C. ; Greeley, George H. / Growth hormone upregulates gastrin and peptide YY gene expression. In: American Journal of Physiology - Endocrinology and Metabolism. 1996 ; Vol. 271, No. 3 34-3.
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