Growth reconstitution following antiretroviral therapy and nutritional supplementation: Systematic review and meta-analysis

Christine J. McGrath, Lara Diener, Barbra A. Richardson, Elizabeth Peacock-Chambers, Grace C. John-Stewart

    Research output: Contribution to journalArticle

    18 Scopus citations

    Abstract

    Objective: As antiretroviral therapy (ART) expands for HIV-infected children, it is important to determine its impact on growth. We quantified growth and its determinants following ART in resource-limited (RLS) and developed settings. Design: Systematic review and meta-analysis. Methods: We searched publications reporting growth [weight-for-age (WAZ), height-for-age (HAZ), and weight-for-height (WHZ) z scores] in HIV-infected children following ART through August 2014. Inclusion criteria were as follows: younger than 18 years; ART; at least 20 patients; growth at ART; and post-ART growth. Standardized and overall weighted mean differences were calculated using random-effects models. Results: A total of 67 articles were eligible (RLS=54; developed settings=13). Mean age was 5.8 years, and comparable between settings (P=0.90). Baseline growth was substantially lower in RLS vs. developed settings (WAZ-2.1 vs.-0.5; HAZ-2.2 vs.-0.9; both P

    Original languageEnglish (US)
    Pages (from-to)2009-2023
    Number of pages15
    JournalAIDS
    Volume29
    Issue number15
    DOIs
    StatePublished - Sep 24 2015

    Keywords

    • antiretroviral therapy
    • growth
    • meta-analysis
    • nutritional supplementation
    • pediatric HIV
    • systematic review

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Immunology
    • Infectious Diseases

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    McGrath, C. J., Diener, L., Richardson, B. A., Peacock-Chambers, E., & John-Stewart, G. C. (2015). Growth reconstitution following antiretroviral therapy and nutritional supplementation: Systematic review and meta-analysis. AIDS, 29(15), 2009-2023. https://doi.org/10.1097/QAD.0000000000000783