GU receptors of double helices mediate tRNA movement in the ribosome

Matthieu Gagnon, Sergey V. Steinberg

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

A new RNA structural motif consisting of two double helices closely packed via minor grooves is found in many places in the ribosome structure. The packing requires that a GU base pair in one helix be packed against a Watson-Crick pair in the other helix. Two such motifs mediate the interaction of the P- and E-tRNA with the large ribosomal subunit. Analysis of the particular positions of these two motifs in view of the available data on occupancy of tRNA-binding sites and structural changes in the ribosome during the elongation cycle suggests a distinct role for each motif in tRNA translocation.

Original languageEnglish (US)
Pages (from-to)873-877
Number of pages5
JournalRNA
Volume8
Issue number7
DOIs
StatePublished - Jul 30 2002
Externally publishedYes

Keywords

  • Double helix packing
  • GU base pair
  • Ribosomal RNA
  • Ribosomal translocation
  • Ribosome structure

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology

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