GU receptors of double helices mediate tRNA movement in the ribosome

Matthieu Gagnon, Sergey V. Steinberg

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

A new RNA structural motif consisting of two double helices closely packed via minor grooves is found in many places in the ribosome structure. The packing requires that a GU base pair in one helix be packed against a Watson-Crick pair in the other helix. Two such motifs mediate the interaction of the P- and E-tRNA with the large ribosomal subunit. Analysis of the particular positions of these two motifs in view of the available data on occupancy of tRNA-binding sites and structural changes in the ribosome during the elongation cycle suggests a distinct role for each motif in tRNA translocation.

Original languageEnglish (US)
Pages (from-to)873-877
Number of pages5
JournalRNA
Volume8
Issue number7
DOIs
StatePublished - Jul 30 2002
Externally publishedYes

Fingerprint

Transfer RNA
Ribosomes
Large Ribosome Subunits
Nucleotide Motifs
Base Pairing
Binding Sites

Keywords

  • Double helix packing
  • GU base pair
  • Ribosomal RNA
  • Ribosomal translocation
  • Ribosome structure

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology

Cite this

GU receptors of double helices mediate tRNA movement in the ribosome. / Gagnon, Matthieu; Steinberg, Sergey V.

In: RNA, Vol. 8, No. 7, 30.07.2002, p. 873-877.

Research output: Contribution to journalArticle

Gagnon, Matthieu ; Steinberg, Sergey V. / GU receptors of double helices mediate tRNA movement in the ribosome. In: RNA. 2002 ; Vol. 8, No. 7. pp. 873-877.
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