Guidelines for sampling, measuring and reporting ionized magnesium in undiluted serum, plasma or blood: International Federation of Clinical Chemistry and Laboratory Medicine (IFCC): IFCC Scientific Division, Committee on Point of Care Testing

Mohammed C. Ben Rayana; Robert W. Burnett; Arthur K. Covington; Paul D'Orazio; Niels Fogh-Andersen; Ellis Jacobs; Wolf R. Külpmann; Katsuhiko Kuwa; Lasse Larsson; Andrzej Lewenstam; Anton H.J. Maas; Gerhard Mager; Jerzy H.J. Naskalski; Anthony O. Okorodudu; Christoph Ritter; Andrew St John

doi:10.1515/CCLM.2005.098

Guidelines for sampling, measuring and reporting ionized magnesium in undiluted serum, plasma or blood: International Federation of Clinical Chemistry and Laboratory Medicine (IFCC): IFCC Scientific Division, Committee on Point of Care Testing

Mohammed C. Ben Rayana, Robert W. Burnett, Arthur K. Covington, Paul D'Orazio, Niels Fogh-Andersen, Ellis Jacobs, Wolf R. Külpmann, Katsuhiko Kuwa, Lasse Larsson, Andrzej Lewenstam, Anton H.J. Maas, Gerhard Mager, Jerzy H.J. Naskalski, Anthony O. Okorodudu, Christoph Ritter, Andrew St John

Pathology

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

All analyzers with ion-selective electrodes for ionized magnesium (iMg) should yield comparable and unbiased results. The prerequisite to achieve this goal is to reach consensus on sampling, measurement and reporting. The recommended guidelines for sampling, measurement and reporting iMg in plasma ("plasma" refers to circulating plasma and the forms in which it is sampled: the plasma phase of anticoagulated whole blood, plasma separated from blood cells, or serum) or blood, referring to the substance concentration of iMg in the calibrants, will provide results for iMg that are approximately 3% greater than its true concentration, and 4% less than its true molality. Binding of magnesium to proteins and ligands in plasma and blood is pH-dependent. Therefore, pH should be simultaneously measured to allow adjustment of iMg concentration to pH 7.4. The substance concentration of iMg may be physiologically and consequently clinically more relevant than the substance concentration of total magnesium.

Original language	English (US)
Pages (from-to)	564-569
Number of pages	6
Journal	Clinical Chemistry and Laboratory Medicine
Volume	43
Issue number	5
DOIs	https://doi.org/10.1515/CCLM.2005.098
State	Published - May 2005

Keywords

Erythrocyte
Heparin
Influence factors
Interference
Ion-selective electrode
Ionized calcium
Ionized magnesium
Lipophilic anions
Liquid junction potential
Protein
Sampling
Silicone
Sodium
pH

ASJC Scopus subject areas

Clinical Biochemistry
Biochemistry, medical

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Ben Rayana, M. C., Burnett, R. W., Covington, A. K., D'Orazio, P., Fogh-Andersen, N., Jacobs, E., Külpmann, W. R., Kuwa, K., Larsson, L., Lewenstam, A., Maas, A. H. J., Mager, G., Naskalski, J. H. J., Okorodudu, A. O., Ritter, C., & St John, A. (2005). Guidelines for sampling, measuring and reporting ionized magnesium in undiluted serum, plasma or blood: International Federation of Clinical Chemistry and Laboratory Medicine (IFCC): IFCC Scientific Division, Committee on Point of Care Testing. Clinical Chemistry and Laboratory Medicine, 43(5), 564-569. https://doi.org/10.1515/CCLM.2005.098

Guidelines for sampling, measuring and reporting ionized magnesium in undiluted serum, plasma or blood: International Federation of Clinical Chemistry and Laboratory Medicine (IFCC): IFCC Scientific Division, Committee on Point of Care Testing. / Ben Rayana, Mohammed C.; Burnett, Robert W.; Covington, Arthur K. et al.
In: Clinical Chemistry and Laboratory Medicine, Vol. 43, No. 5, 05.2005, p. 564-569.

Research output: Contribution to journal › Article › peer-review

Ben Rayana, MC, Burnett, RW, Covington, AK, D'Orazio, P, Fogh-Andersen, N, Jacobs, E, Külpmann, WR, Kuwa, K, Larsson, L, Lewenstam, A, Maas, AHJ, Mager, G, Naskalski, JHJ, Okorodudu, AO, Ritter, C & St John, A 2005, 'Guidelines for sampling, measuring and reporting ionized magnesium in undiluted serum, plasma or blood: International Federation of Clinical Chemistry and Laboratory Medicine (IFCC): IFCC Scientific Division, Committee on Point of Care Testing', Clinical Chemistry and Laboratory Medicine, vol. 43, no. 5, pp. 564-569. https://doi.org/10.1515/CCLM.2005.098

Ben Rayana MC, Burnett RW, Covington AK, D'Orazio P, Fogh-Andersen N, Jacobs E et al. Guidelines for sampling, measuring and reporting ionized magnesium in undiluted serum, plasma or blood: International Federation of Clinical Chemistry and Laboratory Medicine (IFCC): IFCC Scientific Division, Committee on Point of Care Testing. Clinical Chemistry and Laboratory Medicine. 2005 May;43(5):564-569. doi: 10.1515/CCLM.2005.098

Ben Rayana, Mohammed C. ; Burnett, Robert W. ; Covington, Arthur K. et al. / Guidelines for sampling, measuring and reporting ionized magnesium in undiluted serum, plasma or blood : International Federation of Clinical Chemistry and Laboratory Medicine (IFCC): IFCC Scientific Division, Committee on Point of Care Testing. In: Clinical Chemistry and Laboratory Medicine. 2005 ; Vol. 43, No. 5. pp. 564-569.

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abstract = "All analyzers with ion-selective electrodes for ionized magnesium (iMg) should yield comparable and unbiased results. The prerequisite to achieve this goal is to reach consensus on sampling, measurement and reporting. The recommended guidelines for sampling, measurement and reporting iMg in plasma ({"}plasma{"} refers to circulating plasma and the forms in which it is sampled: the plasma phase of anticoagulated whole blood, plasma separated from blood cells, or serum) or blood, referring to the substance concentration of iMg in the calibrants, will provide results for iMg that are approximately 3% greater than its true concentration, and 4% less than its true molality. Binding of magnesium to proteins and ligands in plasma and blood is pH-dependent. Therefore, pH should be simultaneously measured to allow adjustment of iMg concentration to pH 7.4. The substance concentration of iMg may be physiologically and consequently clinically more relevant than the substance concentration of total magnesium.",

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Guidelines for sampling, measuring and reporting ionized magnesium in undiluted serum, plasma or blood: International Federation of Clinical Chemistry and Laboratory Medicine (IFCC): IFCC Scientific Division, Committee on Point of Care Testing

Abstract

Keywords

ASJC Scopus subject areas

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