Guidelines for sampling, measuring and reporting ionized magnesium in undiluted serum, plasma or blood: International Federation of Clinical Chemistry and Laboratory Medicine (IFCC): IFCC Scientific Division, Committee on Point of Care Testing

Mohammed C. Ben Rayana, Robert W. Burnett, Arthur K. Covington, Paul D'Orazio, Niels Fogh-Andersen, Ellis Jacobs, Wolf R. Külpmann, Katsuhiko Kuwa, Lasse Larsson, Andrzej Lewenstam, Anton H J Maas, Gerhard Mager, Jerzy H J Naskalski, Anthony Okorodudu, Christoph Ritter, Andrew St John

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

All analyzers with ion-selective electrodes for ionized magnesium (iMg) should yield comparable and unbiased results. The prerequisite to achieve this goal is to reach consensus on sampling, measurement and reporting. The recommended guidelines for sampling, measurement and reporting iMg in plasma ("plasma" refers to circulating plasma and the forms in which it is sampled: the plasma phase of anticoagulated whole blood, plasma separated from blood cells, or serum) or blood, referring to the substance concentration of iMg in the calibrants, will provide results for iMg that are approximately 3% greater than its true concentration, and 4% less than its true molality. Binding of magnesium to proteins and ligands in plasma and blood is pH-dependent. Therefore, pH should be simultaneously measured to allow adjustment of iMg concentration to pH 7.4. The substance concentration of iMg may be physiologically and consequently clinically more relevant than the substance concentration of total magnesium.

Original languageEnglish (US)
Pages (from-to)564-569
Number of pages6
JournalClinical Chemistry and Laboratory Medicine
Volume43
Issue number5
DOIs
StatePublished - May 2005
Externally publishedYes

Fingerprint

Clinical laboratories
Clinical Chemistry
Magnesium
Medicine
Blood
Guidelines
Sampling
Plasmas
Testing
Serum
Ion-Selective Electrodes
Point-of-Care Testing
Blood Cells
Cells
Ligands

Keywords

  • Erythrocyte
  • Heparin
  • Influence factors
  • Interference
  • Ion-selective electrode
  • Ionized calcium
  • Ionized magnesium
  • Lipophilic anions
  • Liquid junction potential
  • pH
  • Protein
  • Sampling
  • Silicone
  • Sodium

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

Guidelines for sampling, measuring and reporting ionized magnesium in undiluted serum, plasma or blood : International Federation of Clinical Chemistry and Laboratory Medicine (IFCC): IFCC Scientific Division, Committee on Point of Care Testing. / Ben Rayana, Mohammed C.; Burnett, Robert W.; Covington, Arthur K.; D'Orazio, Paul; Fogh-Andersen, Niels; Jacobs, Ellis; Külpmann, Wolf R.; Kuwa, Katsuhiko; Larsson, Lasse; Lewenstam, Andrzej; Maas, Anton H J; Mager, Gerhard; Naskalski, Jerzy H J; Okorodudu, Anthony; Ritter, Christoph; St John, Andrew.

In: Clinical Chemistry and Laboratory Medicine, Vol. 43, No. 5, 05.2005, p. 564-569.

Research output: Contribution to journalArticle

Ben Rayana, MC, Burnett, RW, Covington, AK, D'Orazio, P, Fogh-Andersen, N, Jacobs, E, Külpmann, WR, Kuwa, K, Larsson, L, Lewenstam, A, Maas, AHJ, Mager, G, Naskalski, JHJ, Okorodudu, A, Ritter, C & St John, A 2005, 'Guidelines for sampling, measuring and reporting ionized magnesium in undiluted serum, plasma or blood: International Federation of Clinical Chemistry and Laboratory Medicine (IFCC): IFCC Scientific Division, Committee on Point of Care Testing', Clinical Chemistry and Laboratory Medicine, vol. 43, no. 5, pp. 564-569. https://doi.org/10.1515/CCLM.2005.098
Ben Rayana, Mohammed C. ; Burnett, Robert W. ; Covington, Arthur K. ; D'Orazio, Paul ; Fogh-Andersen, Niels ; Jacobs, Ellis ; Külpmann, Wolf R. ; Kuwa, Katsuhiko ; Larsson, Lasse ; Lewenstam, Andrzej ; Maas, Anton H J ; Mager, Gerhard ; Naskalski, Jerzy H J ; Okorodudu, Anthony ; Ritter, Christoph ; St John, Andrew. / Guidelines for sampling, measuring and reporting ionized magnesium in undiluted serum, plasma or blood : International Federation of Clinical Chemistry and Laboratory Medicine (IFCC): IFCC Scientific Division, Committee on Point of Care Testing. In: Clinical Chemistry and Laboratory Medicine. 2005 ; Vol. 43, No. 5. pp. 564-569.
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