Gyenge adherencia orális pszichotróp gyógyszerrel kezelt felnőtt bipoláris pácienseknél: a pszichiáterek szerepe jelentősebb, mint más súlyos mentális betegségekben

Translated title of the contribution: Poor Adherence to Oral Psychiatric Medication in Adults with Bipolar Disorder: The Psychiatrist May have More Influence than in Other Severe Mental Illnesses

Carlos DE LAS CUEVAS, Alejandro G. Villasante-Tezanos, Mariano Motuca, Trino Baptista, Judit Lazary, Laszlo Pogany, JOSE DE Leon

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Objective: Medication adherence in bipolar disorder (BD) may be influenced by 6 self-reported dimensions: 1) high/low psychological reactance, 2) high/low internal health locus of control (HLOC), 3) high/low doctor HLOC, 4) pharmacophobia, 5) pharmacophilia, and 6) skepticism about a specific medication. This study in Spain, Argentina, and Venezuela included 142 outpatients with BD prescribed 320 psychiatric medications and 1230 other psychiatric outpatients prescribed 2134 medications. Methods: Logistic regression models included adherence for each psychiatric medication, measured by the Sidorkiewicz Adherence Tool as the dependent variable. The models provided adjusted odds ratios (ORs) of dichotomous independent variables: clinical variables and 6 self-reported dimensions. Results: ORs significant in both groups were: 1) high doctor HLOC (OR=1.87 in BD, OR=1.25 in other patients), 2) high psychological reactance (respectively OR=0.572, OR=0.798), 3) pharmacophobia (respectively OR=0.361, OR=0.614), and 4) skepticism about a specific medication (respectively OR=0.300, OR=0.556). Two ORs were only significant in BD patients: medication duration > 1 year (OR=0.449), and extreme polypharmacy (OR=2.49). The study included 104 BD patients prescribed 122 mood stabilizers and 136 other patients prescribed 140 mood stabilizers. Two ORs were significant for mood stabilizer adherence only in BD patients: high doctor HLOC and skepticism (respective ORs=2.38, OR=0.390). The study included 87 BD patients prescribed 97 antipsychotics and 417 other patients prescribed 458 antipsychotics. Four ORs were significant for antipsychotic adherence only in the BD group. Conclusions: Future studies of adherence to all/specific medications should explore the specificity/commonality of these dimensions, particularly doctor HLOC, in BD versus other psychiatric patients.

Translated title of the contributionPoor Adherence to Oral Psychiatric Medication in Adults with Bipolar Disorder: The Psychiatrist May have More Influence than in Other Severe Mental Illnesses
Original languageHungarian
Pages (from-to)347-362
Number of pages16
JournalNeuropsychopharmacologia Hungarica
Volume23
Issue number4
StatePublished - Dec 2021

Keywords

  • Attitude to health
  • Bipolar disorder
  • Health behavior
  • Medication adherence
  • Psychopharmacology

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Clinical Neurology

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