H19X-encoded miR-424(322)/-503 cluster: emerging roles in cell differentiation, proliferation, plasticity and metabolism

Fan Wang; Rui Liang; Neha Tandon; Elizabeth R. Matthews; Shreesti Shrestha; Jiao Yang; Benjamin Soibam; Jin Yang; Yu Liu

doi:10.1007/s00018-018-2971-0

H19X-encoded miR-424(322)/-503 cluster: emerging roles in cell differentiation, proliferation, plasticity and metabolism

Fan Wang, Rui Liang, Neha Tandon, Elizabeth R. Matthews, Shreesti Shrestha, Jiao Yang, Benjamin Soibam, Jin Yang, Yu Liu

Research output: Contribution to journal › Review article › peer-review

52 Scopus citations

Abstract

miR-424(322)/-503 are mammal-specific members of the extended miR-15/107 microRNA family. They form a co-expression network with the imprinted lncRNA H19 in tetrapods. miR-424(322)/-503 regulate fundamental cellular processes including cell cycle, epithelial-to-mesenchymal transition, hypoxia and other stress response. They control tissue differentiation (cardiomyocyte, skeletal muscle, monocyte) and remodeling (mammary gland involution), and paradoxically participate in tumor initiation and progression. Expression of miR-424(322)/-503 is governed by unique mechanisms involving sex hormones. Here, we summarize current literature and provide a primer for future endeavors.

Original language	English (US)
Pages (from-to)	903-920
Number of pages	18
Journal	Cellular and Molecular Life Sciences
Volume	76
Issue number	5
DOIs	https://doi.org/10.1007/s00018-018-2971-0
State	Published - Mar 15 2019
Externally published	Yes

Keywords

EMT
H19X
Hypoxia
Tumor suppressor gene
miR-322
miR-424
miR-503

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Pharmacology
Cellular and Molecular Neuroscience
Cell Biology

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10.1007/s00018-018-2971-0

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title = "H19X-encoded miR-424(322)/-503 cluster: emerging roles in cell differentiation, proliferation, plasticity and metabolism",

abstract = "miR-424(322)/-503 are mammal-specific members of the extended miR-15/107 microRNA family. They form a co-expression network with the imprinted lncRNA H19 in tetrapods. miR-424(322)/-503 regulate fundamental cellular processes including cell cycle, epithelial-to-mesenchymal transition, hypoxia and other stress response. They control tissue differentiation (cardiomyocyte, skeletal muscle, monocyte) and remodeling (mammary gland involution), and paradoxically participate in tumor initiation and progression. Expression of miR-424(322)/-503 is governed by unique mechanisms involving sex hormones. Here, we summarize current literature and provide a primer for future endeavors.",

keywords = "EMT, H19X, Hypoxia, Tumor suppressor gene, miR-322, miR-424, miR-503",

author = "Fan Wang and Rui Liang and Neha Tandon and Matthews, {Elizabeth R.} and Shreesti Shrestha and Jiao Yang and Benjamin Soibam and Jin Yang and Yu Liu",

note = "Publisher Copyright: {\textcopyright} 2018, The Author(s).",

year = "2019",

month = mar,

day = "15",

doi = "10.1007/s00018-018-2971-0",

language = "English (US)",

volume = "76",

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TY - JOUR

T1 - H19X-encoded miR-424(322)/-503 cluster

T2 - emerging roles in cell differentiation, proliferation, plasticity and metabolism

AU - Wang, Fan

AU - Liang, Rui

AU - Tandon, Neha

AU - Matthews, Elizabeth R.

AU - Shrestha, Shreesti

AU - Yang, Jiao

AU - Soibam, Benjamin

AU - Yang, Jin

AU - Liu, Yu

PY - 2019/3/15

Y1 - 2019/3/15

N2 - miR-424(322)/-503 are mammal-specific members of the extended miR-15/107 microRNA family. They form a co-expression network with the imprinted lncRNA H19 in tetrapods. miR-424(322)/-503 regulate fundamental cellular processes including cell cycle, epithelial-to-mesenchymal transition, hypoxia and other stress response. They control tissue differentiation (cardiomyocyte, skeletal muscle, monocyte) and remodeling (mammary gland involution), and paradoxically participate in tumor initiation and progression. Expression of miR-424(322)/-503 is governed by unique mechanisms involving sex hormones. Here, we summarize current literature and provide a primer for future endeavors.

AB - miR-424(322)/-503 are mammal-specific members of the extended miR-15/107 microRNA family. They form a co-expression network with the imprinted lncRNA H19 in tetrapods. miR-424(322)/-503 regulate fundamental cellular processes including cell cycle, epithelial-to-mesenchymal transition, hypoxia and other stress response. They control tissue differentiation (cardiomyocyte, skeletal muscle, monocyte) and remodeling (mammary gland involution), and paradoxically participate in tumor initiation and progression. Expression of miR-424(322)/-503 is governed by unique mechanisms involving sex hormones. Here, we summarize current literature and provide a primer for future endeavors.

KW - EMT

KW - H19X

KW - Hypoxia

KW - Tumor suppressor gene

KW - miR-322

KW - miR-424

KW - miR-503

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U2 - 10.1007/s00018-018-2971-0

DO - 10.1007/s00018-018-2971-0

M3 - Review article

C2 - 30474694

AN - SCOPUS:85057323948

SN - 1420-682X

VL - 76

SP - 903

EP - 920

JO - Cellular and Molecular Life Sciences

JF - Cellular and Molecular Life Sciences

IS - 5

ER -

H19X-encoded miR-424(322)/-503 cluster: emerging roles in cell differentiation, proliferation, plasticity and metabolism

Abstract

Keywords

ASJC Scopus subject areas

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