H19X-encoded miR-424(322)/-503 cluster: emerging roles in cell differentiation, proliferation, plasticity and metabolism

Fan Wang, Rui Liang, Neha Tandon, Elizabeth R. Matthews, Shreesti Shrestha, Jiao Yang, Benjamin Soibam, Jin Yang, Yu Liu

Research output: Contribution to journalReview articlepeer-review

34 Scopus citations

Abstract

miR-424(322)/-503 are mammal-specific members of the extended miR-15/107 microRNA family. They form a co-expression network with the imprinted lncRNA H19 in tetrapods. miR-424(322)/-503 regulate fundamental cellular processes including cell cycle, epithelial-to-mesenchymal transition, hypoxia and other stress response. They control tissue differentiation (cardiomyocyte, skeletal muscle, monocyte) and remodeling (mammary gland involution), and paradoxically participate in tumor initiation and progression. Expression of miR-424(322)/-503 is governed by unique mechanisms involving sex hormones. Here, we summarize current literature and provide a primer for future endeavors.

Original languageEnglish (US)
Pages (from-to)903-920
Number of pages18
JournalCellular and Molecular Life Sciences
Volume76
Issue number5
DOIs
StatePublished - Mar 15 2019
Externally publishedYes

Keywords

  • EMT
  • H19X
  • Hypoxia
  • Tumor suppressor gene
  • miR-322
  • miR-424
  • miR-503

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology

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