Hacker within! Ehrlichia chaffeensis effector driven phagocyte reprogramming strategy

Taslima T. Lina, Tierra Farris, Tian Luo, Shubhajit Mitra, Bing Zhu, Jere W. McBride

Research output: Contribution to journalReview article

13 Scopus citations

Abstract

Ehrlichia chaffeensis is a small, gram negative, obligately intracellular bacterium that preferentially infects mononuclear phagocytes. It is the etiologic agent of human monocytotropic ehrlichiosis (HME), an emerging life-threatening tick-borne zoonosis. Mechanisms by which E. chaffeensis establishes intracellular infection, and avoids host defenses are not well understood, but involve functionally relevant host-pathogen interactions associated with tandem and ankyrin repeat effector proteins. In this review, we discuss the recent advances in our understanding of the molecular and cellular mechanisms that underlie Ehrlichia host cellular reprogramming strategies that enable intracellular survival.

Original languageEnglish (US)
Article number58
JournalFrontiers in Cellular and Infection Microbiology
Volume6
Issue numberMAY
DOIs
StatePublished - May 31 2016

Keywords

  • Cell signaling
  • Ehrlichia chaffeensis
  • Epigenetics
  • Innate immune response
  • Post translational modification (PTM)
  • Secretion system
  • Tandem repeat proteins (TRPs)

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Microbiology (medical)
  • Infectious Diseases

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