Haemaphysalis longicornis ticks as reservoir and vector of severe fever with thrombocytopenia syndrome virus in China

Li Mei Luo, Li Zhao, Hong Ling Wen, Zhen Tang Zhang, Jian Wei Liu, Li Zhu Fang, Zai Feng Xue, Dong Qiang Ma, Xiao Shuang Zhang, Shu Jun Ding, Xiao Ying Lei, Xue Jie Yu

Research output: Contribution to journalArticle

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Abstract

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic fever in East Asia caused by SFTS virus (SFTSV), a newly discovered phlebovirus. The Haemaphysalis longicornis tick has been suspected to be the vector of SFTSV. To determine whether SFTSV can be transmitted among ticks, from ticks to animals, and from animals to ticks, we conducted transmission studies between developmental stages of H. longicornis ticks and between ticks and mice. Using reverse transcription PCR, we also analyzed the prevalence of SFTSV infection among H. longicornis ticks collected from vegetation in Shandong Province, China. Our results showed a low prevalence of SFTSV among collected ticks (0.2%, 8/3,300 ticks), and we showed that ticks fed on SFTSV-infected mice could acquire the virus and transstadially and transovarially transmit it to other developmental stages of ticks. Furthermore, SFTSVinfected ticks could transmit the virus to mice during feeding. Our findings indicate ticks could serve as a vector and reservoir of SFTSV.

Original languageEnglish (US)
Pages (from-to)1770-1776
Number of pages7
JournalEmerging Infectious Diseases
Volume21
Issue number10
DOIs
StatePublished - Sep 1 2015

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Ticks
Thrombocytopenia
China
Fever
Viruses
Phlebovirus
Far East
Virus Diseases
Reverse Transcription

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Epidemiology

Cite this

Haemaphysalis longicornis ticks as reservoir and vector of severe fever with thrombocytopenia syndrome virus in China. / Luo, Li Mei; Zhao, Li; Wen, Hong Ling; Zhang, Zhen Tang; Liu, Jian Wei; Fang, Li Zhu; Xue, Zai Feng; Ma, Dong Qiang; Zhang, Xiao Shuang; Ding, Shu Jun; Lei, Xiao Ying; Yu, Xue Jie.

In: Emerging Infectious Diseases, Vol. 21, No. 10, 01.09.2015, p. 1770-1776.

Research output: Contribution to journalArticle

Luo, LM, Zhao, L, Wen, HL, Zhang, ZT, Liu, JW, Fang, LZ, Xue, ZF, Ma, DQ, Zhang, XS, Ding, SJ, Lei, XY & Yu, XJ 2015, 'Haemaphysalis longicornis ticks as reservoir and vector of severe fever with thrombocytopenia syndrome virus in China', Emerging Infectious Diseases, vol. 21, no. 10, pp. 1770-1776. https://doi.org/10.3201/eid2110.150126
Luo, Li Mei ; Zhao, Li ; Wen, Hong Ling ; Zhang, Zhen Tang ; Liu, Jian Wei ; Fang, Li Zhu ; Xue, Zai Feng ; Ma, Dong Qiang ; Zhang, Xiao Shuang ; Ding, Shu Jun ; Lei, Xiao Ying ; Yu, Xue Jie. / Haemaphysalis longicornis ticks as reservoir and vector of severe fever with thrombocytopenia syndrome virus in China. In: Emerging Infectious Diseases. 2015 ; Vol. 21, No. 10. pp. 1770-1776.
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