Haemodynamic response to magnesium administration in mineralocorticoid-salt and two-kidney, one clip renovascular hypertension

D. J. DiPette, K. Simpson, A. Rogers, O. B. Holland

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Recent interest has centred on the role of divalent cations in hypertension, particularly in relation to the renin-angiotensin system. This study was undertaken to determine the hypotensive effect of magnesium administration in relation to the state of activation of the renin-angiotensin system. The mean blood pressure (MBP) and heart rate (HR) response to either the acute intravenous administration of a pharmacological dose of MgSO4 or vehicle was determined in conscious mineralocorticoid-salt (DOCA-salt, low-renin) and two-kidney, one clip renovascular, high-renin hypertensive rats. Baseline MBP was higher in the renovascular than in the DOCA-salt rats, while there was no difference in HR or serum Mg concentration between the two. Following administration of MgSO4, serum Mg increased equally in both the DOCA-salt (1.4 ± 0.8 to 4.9 ± 0.16 mEq/l; P < 0.001) and in the renovascular rats (1.8 ± 0.14 to 4.4 ± 0.27 mEq/l; P < 0.001). Magnesium administration significantly lowered MBP over the 1-h infusion in the DOCA-salt (167 ± 8 to 145 ± 5 mmHg, P < 0.001) but not the renovascular hypertensive rats (191 ± 5 to 183 ± 4, NS). We conclude that the blood pressure lowering effect of Mg is related, in part, to the state of activation of the renin-angiotensin system. The mechanism of this differential effect remains to be determined.

Original languageEnglish
Pages (from-to)413-417
Number of pages5
JournalJournal of Hypertension
Volume6
Issue number5
StatePublished - 1988

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Mineralocorticoids
Renovascular Hypertension
Desoxycorticosterone Acetate
Surgical Instruments
Magnesium
Salts
Hemodynamics
Kidney
Renin-Angiotensin System
Blood Pressure
Renin
Heart Rate
Hypertension
Divalent Cations
Serum
Intravenous Administration
Pharmacology

ASJC Scopus subject areas

  • Endocrinology
  • Internal Medicine

Cite this

Haemodynamic response to magnesium administration in mineralocorticoid-salt and two-kidney, one clip renovascular hypertension. / DiPette, D. J.; Simpson, K.; Rogers, A.; Holland, O. B.

In: Journal of Hypertension, Vol. 6, No. 5, 1988, p. 413-417.

Research output: Contribution to journalArticle

DiPette, D. J. ; Simpson, K. ; Rogers, A. ; Holland, O. B. / Haemodynamic response to magnesium administration in mineralocorticoid-salt and two-kidney, one clip renovascular hypertension. In: Journal of Hypertension. 1988 ; Vol. 6, No. 5. pp. 413-417.
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