Hansenula polymorpha infection in a child with chronic granulomatous disease

M. R. McGinnis, David Walker, J. D. Folds

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

In a patient with chronic granulomatous disease of childhood documented by the nitroblue tetrazolium test, an infection of the mediastinal lymph nodes developed that was caused by Hansenula polymorpha, an ascomycetous yeast. To our knowledge, this yeast has not been previously shown to be an etiologic agent of disease in man. The diagnosis was made by growing the yeast from cultures of several biopsy specimens collected at the time of thoracotomy. Susceptibility testing showed that the yeast was sensitive to amphotericin B. Treatment with amphotericin B reversed this life-threatening episode.

Original languageEnglish (US)
Pages (from-to)290-292
Number of pages3
JournalArchives of Pathology and Laboratory Medicine
Volume104
Issue number6
StatePublished - 1980
Externally publishedYes

Fingerprint

Chronic Granulomatous Disease
Pichia
Yeasts
Amphotericin B
Infection
Nitroblue Tetrazolium
Thoracotomy
Lymph Nodes
Biopsy
Therapeutics

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

Cite this

Hansenula polymorpha infection in a child with chronic granulomatous disease. / McGinnis, M. R.; Walker, David; Folds, J. D.

In: Archives of Pathology and Laboratory Medicine, Vol. 104, No. 6, 1980, p. 290-292.

Research output: Contribution to journalArticle

@article{c4a578d314824f83b2bcf7a1d8ce8a23,
title = "Hansenula polymorpha infection in a child with chronic granulomatous disease",
abstract = "In a patient with chronic granulomatous disease of childhood documented by the nitroblue tetrazolium test, an infection of the mediastinal lymph nodes developed that was caused by Hansenula polymorpha, an ascomycetous yeast. To our knowledge, this yeast has not been previously shown to be an etiologic agent of disease in man. The diagnosis was made by growing the yeast from cultures of several biopsy specimens collected at the time of thoracotomy. Susceptibility testing showed that the yeast was sensitive to amphotericin B. Treatment with amphotericin B reversed this life-threatening episode.",
author = "McGinnis, {M. R.} and David Walker and Folds, {J. D.}",
year = "1980",
language = "English (US)",
volume = "104",
pages = "290--292",
journal = "Archives of Pathology and Laboratory Medicine",
issn = "0003-9985",
publisher = "College of American Pathologists",
number = "6",

}

TY - JOUR

T1 - Hansenula polymorpha infection in a child with chronic granulomatous disease

AU - McGinnis, M. R.

AU - Walker, David

AU - Folds, J. D.

PY - 1980

Y1 - 1980

N2 - In a patient with chronic granulomatous disease of childhood documented by the nitroblue tetrazolium test, an infection of the mediastinal lymph nodes developed that was caused by Hansenula polymorpha, an ascomycetous yeast. To our knowledge, this yeast has not been previously shown to be an etiologic agent of disease in man. The diagnosis was made by growing the yeast from cultures of several biopsy specimens collected at the time of thoracotomy. Susceptibility testing showed that the yeast was sensitive to amphotericin B. Treatment with amphotericin B reversed this life-threatening episode.

AB - In a patient with chronic granulomatous disease of childhood documented by the nitroblue tetrazolium test, an infection of the mediastinal lymph nodes developed that was caused by Hansenula polymorpha, an ascomycetous yeast. To our knowledge, this yeast has not been previously shown to be an etiologic agent of disease in man. The diagnosis was made by growing the yeast from cultures of several biopsy specimens collected at the time of thoracotomy. Susceptibility testing showed that the yeast was sensitive to amphotericin B. Treatment with amphotericin B reversed this life-threatening episode.

UR - http://www.scopus.com/inward/record.url?scp=0018894920&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018894920&partnerID=8YFLogxK

M3 - Article

C2 - 6892867

AN - SCOPUS:0018894920

VL - 104

SP - 290

EP - 292

JO - Archives of Pathology and Laboratory Medicine

JF - Archives of Pathology and Laboratory Medicine

SN - 0003-9985

IS - 6

ER -