Hantavirus pulmonary syndrome associated with Monongahela virus, Pennsylvania

Luther V. Rhodes, Cinnia Huang, Angela J. Sanchez, Stuart T. Nichol, Sherif R. Zaki, Thomas G. Ksiazek, J. G. Humphreys, James J. Freeman, Kenneth R. Knecht

Research output: Contribution to journalArticle

30 Scopus citations


The first two recognized cases of rapidly fatal hantavirus pulmonary syndrome in Pennsylvania occurred within an 8-month period in 1997. Illness in the two patients was confirmed by immunohistochemical techniques on autopsy material. Reverse transcription-polymerase chain reaction analysis of tissue from one patient and environmentally associated Peromyscus leucopus (white-footed mouse) identified the Monongahela virus variant. Physicians should be vigilant for such Monongahela virus-associated cases in the eastern United States and Canada, particularly in the Appalachian region.

Original languageEnglish (US)
Pages (from-to)616-621
Number of pages6
JournalEmerging infectious diseases
Issue number6
StatePublished - Dec 1 2000
Externally publishedYes


ASJC Scopus subject areas

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Rhodes, L. V., Huang, C., Sanchez, A. J., Nichol, S. T., Zaki, S. R., Ksiazek, T. G., Humphreys, J. G., Freeman, J. J., & Knecht, K. R. (2000). Hantavirus pulmonary syndrome associated with Monongahela virus, Pennsylvania. Emerging infectious diseases, 6(6), 616-621.