Hantavirus pulmonary syndrome in northwestern Argentina

Circulation of Laguna Negra virus associated with Calomys callosus

Silvana Levis, Jorge Garcia, Noemí Pini, Gladys Calderón, Josefina Ramírez, Daniel Bravo, Stephen St. Jeor, Carlos Ripoll, Mariana Bego, Elena Lozano, Rubén Barquez, Thomas Ksiazek, Delia Enria

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

The purpose of this study was to characterize the hantaviruses circulating in northwestern Argentina. Human and rodent studies were conducted in Yuto, where most cases of hantavirus pulmonary syndrome (HPS) occur. Partial virus genome sequences were obtained from the blood of 12 cases of HPS, and from the lungs of 4 Calomys callosus and 1 Akodon simulator. Phylogenetic analysis showed that three genotypes associated with HPS circulate in Yuto. Laguna Negra (LN) virus, associated with C. laucha in Paraguay, was identified for the first time in Argentina; it was recovered from human cases and from C. callosus samples. The high sequence identity between human and rodent samples implicated C. callosus as the primary rodent reservoir for LN virus in Yuto. The genetic analysis showed that the Argentinian LN virus variant differed 16.8% at the nucleotide level and 2.9% at the protein level relative to the Paraguayan LN virus. The other two hantavirus lineages identified were the previously known Bermejo and Orán viruses.

Original languageEnglish (US)
Pages (from-to)658-663
Number of pages6
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume71
Issue number5
StatePublished - Nov 2004
Externally publishedYes

Fingerprint

Hantavirus Pulmonary Syndrome
Argentina
Viruses
Hantavirus
Rodentia
Paraguay
Nucleotides
Genotype
Genome
Lung

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Levis, S., Garcia, J., Pini, N., Calderón, G., Ramírez, J., Bravo, D., ... Enria, D. (2004). Hantavirus pulmonary syndrome in northwestern Argentina: Circulation of Laguna Negra virus associated with Calomys callosus. American Journal of Tropical Medicine and Hygiene, 71(5), 658-663.

Hantavirus pulmonary syndrome in northwestern Argentina : Circulation of Laguna Negra virus associated with Calomys callosus. / Levis, Silvana; Garcia, Jorge; Pini, Noemí; Calderón, Gladys; Ramírez, Josefina; Bravo, Daniel; St. Jeor, Stephen; Ripoll, Carlos; Bego, Mariana; Lozano, Elena; Barquez, Rubén; Ksiazek, Thomas; Enria, Delia.

In: American Journal of Tropical Medicine and Hygiene, Vol. 71, No. 5, 11.2004, p. 658-663.

Research output: Contribution to journalArticle

Levis, S, Garcia, J, Pini, N, Calderón, G, Ramírez, J, Bravo, D, St. Jeor, S, Ripoll, C, Bego, M, Lozano, E, Barquez, R, Ksiazek, T & Enria, D 2004, 'Hantavirus pulmonary syndrome in northwestern Argentina: Circulation of Laguna Negra virus associated with Calomys callosus', American Journal of Tropical Medicine and Hygiene, vol. 71, no. 5, pp. 658-663.
Levis, Silvana ; Garcia, Jorge ; Pini, Noemí ; Calderón, Gladys ; Ramírez, Josefina ; Bravo, Daniel ; St. Jeor, Stephen ; Ripoll, Carlos ; Bego, Mariana ; Lozano, Elena ; Barquez, Rubén ; Ksiazek, Thomas ; Enria, Delia. / Hantavirus pulmonary syndrome in northwestern Argentina : Circulation of Laguna Negra virus associated with Calomys callosus. In: American Journal of Tropical Medicine and Hygiene. 2004 ; Vol. 71, No. 5. pp. 658-663.
@article{b5594dbe91394d8e979216e084f403f0,
title = "Hantavirus pulmonary syndrome in northwestern Argentina: Circulation of Laguna Negra virus associated with Calomys callosus",
abstract = "The purpose of this study was to characterize the hantaviruses circulating in northwestern Argentina. Human and rodent studies were conducted in Yuto, where most cases of hantavirus pulmonary syndrome (HPS) occur. Partial virus genome sequences were obtained from the blood of 12 cases of HPS, and from the lungs of 4 Calomys callosus and 1 Akodon simulator. Phylogenetic analysis showed that three genotypes associated with HPS circulate in Yuto. Laguna Negra (LN) virus, associated with C. laucha in Paraguay, was identified for the first time in Argentina; it was recovered from human cases and from C. callosus samples. The high sequence identity between human and rodent samples implicated C. callosus as the primary rodent reservoir for LN virus in Yuto. The genetic analysis showed that the Argentinian LN virus variant differed 16.8{\%} at the nucleotide level and 2.9{\%} at the protein level relative to the Paraguayan LN virus. The other two hantavirus lineages identified were the previously known Bermejo and Or{\'a}n viruses.",
author = "Silvana Levis and Jorge Garcia and Noem{\'i} Pini and Gladys Calder{\'o}n and Josefina Ram{\'i}rez and Daniel Bravo and {St. Jeor}, Stephen and Carlos Ripoll and Mariana Bego and Elena Lozano and Rub{\'e}n Barquez and Thomas Ksiazek and Delia Enria",
year = "2004",
month = "11",
language = "English (US)",
volume = "71",
pages = "658--663",
journal = "American Journal of Tropical Medicine and Hygiene",
issn = "0002-9637",
publisher = "American Society of Tropical Medicine and Hygiene",
number = "5",

}

TY - JOUR

T1 - Hantavirus pulmonary syndrome in northwestern Argentina

T2 - Circulation of Laguna Negra virus associated with Calomys callosus

AU - Levis, Silvana

AU - Garcia, Jorge

AU - Pini, Noemí

AU - Calderón, Gladys

AU - Ramírez, Josefina

AU - Bravo, Daniel

AU - St. Jeor, Stephen

AU - Ripoll, Carlos

AU - Bego, Mariana

AU - Lozano, Elena

AU - Barquez, Rubén

AU - Ksiazek, Thomas

AU - Enria, Delia

PY - 2004/11

Y1 - 2004/11

N2 - The purpose of this study was to characterize the hantaviruses circulating in northwestern Argentina. Human and rodent studies were conducted in Yuto, where most cases of hantavirus pulmonary syndrome (HPS) occur. Partial virus genome sequences were obtained from the blood of 12 cases of HPS, and from the lungs of 4 Calomys callosus and 1 Akodon simulator. Phylogenetic analysis showed that three genotypes associated with HPS circulate in Yuto. Laguna Negra (LN) virus, associated with C. laucha in Paraguay, was identified for the first time in Argentina; it was recovered from human cases and from C. callosus samples. The high sequence identity between human and rodent samples implicated C. callosus as the primary rodent reservoir for LN virus in Yuto. The genetic analysis showed that the Argentinian LN virus variant differed 16.8% at the nucleotide level and 2.9% at the protein level relative to the Paraguayan LN virus. The other two hantavirus lineages identified were the previously known Bermejo and Orán viruses.

AB - The purpose of this study was to characterize the hantaviruses circulating in northwestern Argentina. Human and rodent studies were conducted in Yuto, where most cases of hantavirus pulmonary syndrome (HPS) occur. Partial virus genome sequences were obtained from the blood of 12 cases of HPS, and from the lungs of 4 Calomys callosus and 1 Akodon simulator. Phylogenetic analysis showed that three genotypes associated with HPS circulate in Yuto. Laguna Negra (LN) virus, associated with C. laucha in Paraguay, was identified for the first time in Argentina; it was recovered from human cases and from C. callosus samples. The high sequence identity between human and rodent samples implicated C. callosus as the primary rodent reservoir for LN virus in Yuto. The genetic analysis showed that the Argentinian LN virus variant differed 16.8% at the nucleotide level and 2.9% at the protein level relative to the Paraguayan LN virus. The other two hantavirus lineages identified were the previously known Bermejo and Orán viruses.

UR - http://www.scopus.com/inward/record.url?scp=10044279335&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=10044279335&partnerID=8YFLogxK

M3 - Article

VL - 71

SP - 658

EP - 663

JO - American Journal of Tropical Medicine and Hygiene

JF - American Journal of Tropical Medicine and Hygiene

SN - 0002-9637

IS - 5

ER -