Hantavirus pulmonary syndrome in northwestern Argentina: Circulation of Laguna Negra virus associated with Calomys callosus

Silvana Levis, Jorge Garcia, Noemí Pini, Gladys Calderón, Josefina Ramírez, Daniel Bravo, Stephen St. Jeor, Carlos Ripoll, Mariana Bego, Elena Lozano, Rubén Barquez, Thomas G. Ksiazek, Delia Enria

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

The purpose of this study was to characterize the hantaviruses circulating in northwestern Argentina. Human and rodent studies were conducted in Yuto, where most cases of hantavirus pulmonary syndrome (HPS) occur. Partial virus genome sequences were obtained from the blood of 12 cases of HPS, and from the lungs of 4 Calomys callosus and 1 Akodon simulator. Phylogenetic analysis showed that three genotypes associated with HPS circulate in Yuto. Laguna Negra (LN) virus, associated with C. laucha in Paraguay, was identified for the first time in Argentina; it was recovered from human cases and from C. callosus samples. The high sequence identity between human and rodent samples implicated C. callosus as the primary rodent reservoir for LN virus in Yuto. The genetic analysis showed that the Argentinian LN virus variant differed 16.8% at the nucleotide level and 2.9% at the protein level relative to the Paraguayan LN virus. The other two hantavirus lineages identified were the previously known Bermejo and Orán viruses.

Original languageEnglish (US)
Pages (from-to)658-663
Number of pages6
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume71
Issue number5
DOIs
StatePublished - Nov 2004

ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases

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    Levis, S., Garcia, J., Pini, N., Calderón, G., Ramírez, J., Bravo, D., St. Jeor, S., Ripoll, C., Bego, M., Lozano, E., Barquez, R., Ksiazek, T. G., & Enria, D. (2004). Hantavirus pulmonary syndrome in northwestern Argentina: Circulation of Laguna Negra virus associated with Calomys callosus. American Journal of Tropical Medicine and Hygiene, 71(5), 658-663. https://doi.org/10.4269/ajtmh.2004.71.658