Hantavirus pulmonary syndrome in Panama: Identification of novel hantaviruses and their likely reservoirs

M. J. Vincent, E. Quiroz, F. Gracia, A. J. Sanchez, Thomas Ksiazek, P. T. Kitsutani, L. A. Ruedas, D. S. Tinnin, L. Caceres, A. Garcia, P. E. Rollin, J. N. Mills, C. J. Peters, S. T. Nichol

Research output: Contribution to journalArticle

108 Citations (Scopus)

Abstract

Hantavirus pulmonary syndrome (HPS), a severe respiratory disease with high mortality caused by rodent-borne hantaviruses, has previously been identified in the United States and Canada as well as central and southern South America. In late 1999 and early 2000, an outbreak of acute illness compatible with HPS was reported in Los Santos, Panama, with the death of 3 of the 12 (25%) suspected cases. Hantavirus-specific antibodies were detected in patient sera, and virus RNA was detected by reverse transcriptase-polymerase chain reaction. Sequence analysis of virus genome N-, G1-, and G2-encoding fragments showed this to be a novel hantavirus, Choclo virus. Serologic and virus genetic analyses of rodents trapped in the area showed Oligoryzomys fulvescens to be the likely reservoir for the HPS-associated Choclo virus. In addition, Zygodontomys brevicauda rodents were shown to harbor another genetically unique hantavirus, Calabazo virus. (C) 2000 Academic Press.

Original languageEnglish (US)
Pages (from-to)14-19
Number of pages6
JournalVirology
Volume277
Issue number1
DOIs
StatePublished - Nov 10 2000
Externally publishedYes

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Hantavirus Pulmonary Syndrome
Hantavirus
Panama
Viruses
Rodentia
Satellite Viruses
South America
RNA Viruses
Reverse Transcriptase Polymerase Chain Reaction
Canada
Disease Outbreaks
Sequence Analysis
Genome
Mortality
Antibodies
Serum

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

Vincent, M. J., Quiroz, E., Gracia, F., Sanchez, A. J., Ksiazek, T., Kitsutani, P. T., ... Nichol, S. T. (2000). Hantavirus pulmonary syndrome in Panama: Identification of novel hantaviruses and their likely reservoirs. Virology, 277(1), 14-19. https://doi.org/10.1006/viro.2000.0563

Hantavirus pulmonary syndrome in Panama : Identification of novel hantaviruses and their likely reservoirs. / Vincent, M. J.; Quiroz, E.; Gracia, F.; Sanchez, A. J.; Ksiazek, Thomas; Kitsutani, P. T.; Ruedas, L. A.; Tinnin, D. S.; Caceres, L.; Garcia, A.; Rollin, P. E.; Mills, J. N.; Peters, C. J.; Nichol, S. T.

In: Virology, Vol. 277, No. 1, 10.11.2000, p. 14-19.

Research output: Contribution to journalArticle

Vincent, MJ, Quiroz, E, Gracia, F, Sanchez, AJ, Ksiazek, T, Kitsutani, PT, Ruedas, LA, Tinnin, DS, Caceres, L, Garcia, A, Rollin, PE, Mills, JN, Peters, CJ & Nichol, ST 2000, 'Hantavirus pulmonary syndrome in Panama: Identification of novel hantaviruses and their likely reservoirs', Virology, vol. 277, no. 1, pp. 14-19. https://doi.org/10.1006/viro.2000.0563
Vincent, M. J. ; Quiroz, E. ; Gracia, F. ; Sanchez, A. J. ; Ksiazek, Thomas ; Kitsutani, P. T. ; Ruedas, L. A. ; Tinnin, D. S. ; Caceres, L. ; Garcia, A. ; Rollin, P. E. ; Mills, J. N. ; Peters, C. J. ; Nichol, S. T. / Hantavirus pulmonary syndrome in Panama : Identification of novel hantaviruses and their likely reservoirs. In: Virology. 2000 ; Vol. 277, No. 1. pp. 14-19.
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