Hantavirus pulmonary syndrome: The first 100 US cases

Ali S. Khan, Rima F. Khabbaz, Lori R. Armstrong, Robert C. Holman, Sally P. Bauer, Judith Graber, Tara Strine, Gayle Miller, Susan Reef, Jordan Tappero, Pierre E. Rollin, Stuart T. Nichol, Sherif R. Zaki, Ralph T. Bryan, Louisa E. Chapman, C. J. Peters, Thomas G. Ksiazek

Research output: Contribution to journalArticlepeer-review

196 Scopus citations


In the spring of 1993, hantavirus pulmonary syndrome (HPS) 'emerged' in the southwestern United States, where a multiagency investigation led to the rapid description of this new clinical entity and its etiology. Analysis of the first 100 US cases identified showed that the disease was distributed in 21 states, had gone unrecognized since at least 1959, and had a distinct spring-early summer seasonality. Of the infected persons, 54% were male; 63% were Caucasian, 35% were Native American, and 2% were African American. The average age of case-patients was 34.9 years, and 8 were children or adolescents aged ≤ 16 years. The overall case-fatality rate was 52%. There was a 91% concordance among serologic, immunohistochemical, and molecular results. HPS in the United States is caused by at least three newly described pathogenic hantaviruses, each of which has a distinct rodent host, and cases of HPS have been recently recognized in Canada and South America. National surveillance of this sporadic disease remains essential for further defining the epidemiology and clinical spectrum.

Original languageEnglish (US)
Pages (from-to)1297-1303
Number of pages7
JournalJournal of Infectious Diseases
Issue number6
StatePublished - 1996
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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