Haptoglobin phenotype and abnormal uterine artery Doppler in a racially diverse cohort

Tracey L. Weissgerber, Paula L. McGee, Leslie Myatt, John C. Hauth, Michael W. Varner, Ronald J. Wapner, John M. Thorp, Brian M. Mercer, Alan M. Peaceman, Susan M. Ramin, Philip Samuels, Anthony C. Sciscione, Margaret Harper, George Saade, Yoram Sorokin, Natl Inst of Child Hlth and Hum Devmt Matern Fetal Med Units Network Eunice Kennedy Shriver

Research output: Contribution to journalArticle

Abstract

Objective: The anti-oxidant and proangiogenic protein haptoglobin (Hp) is believed to be important for implantation and pregnancy, although its specific role is not known. The three phenotypes (1-1, 2-1 and 2-2) differ in structure and function. Hp 2-2 is associated with increased vascular stiffness in other populations. We examined whether Hp phenotype is associated with abnormal uterine artery Doppler (UAD) in pregnancy. Methods: We conducted a secondary analysis of a preeclampsia prediction cohort nested within a larger placebo-controlled randomized clinical trial of antioxidants for prevention of preeclampsia. We determined Hp phenotype in 2184 women who completed UAD assessments at 17 weeks gestation. Women with notching were re-evaluated for persistent notching at 24 weeks' gestation. Logistic regression was used to assess differences in UAD indices between phenotype groups. Results: Hp phenotype did not significantly influence the odds of having any notch (p = 0.32), bilateral notches (p = 0.72), or a resistance index (p = 0.28) or pulsatility index (p = 0.67) above the 90th percentile at 17 weeks' gestation. Hp phenotype also did not influence the odds of persistent notching at 24 weeks (p = 0.25). Conclusions: Hp phenotype is not associated with abnormal UAD at 17 weeks' gestation or with persistent notching at 24 weeks.

Original languageEnglish (US)
Pages (from-to)1728-1733
Number of pages6
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume27
Issue number17
DOIs
StatePublished - Nov 1 2014

Fingerprint

Uterine Artery
Haptoglobins
Phenotype
Pregnancy
Pre-Eclampsia
Vascular Stiffness
Oxidants
Randomized Controlled Trials
Antioxidants
Logistic Models
Placebos
Population

Keywords

  • Ethnicity
  • Haptoglobin
  • Pregnancy
  • Race
  • Vascular resistance
  • Women

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Weissgerber, T. L., McGee, P. L., Myatt, L., Hauth, J. C., Varner, M. W., Wapner, R. J., ... Eunice Kennedy Shriver, N. I. O. C. H. A. H. D. M. F. M. U. N. (2014). Haptoglobin phenotype and abnormal uterine artery Doppler in a racially diverse cohort. Journal of Maternal-Fetal and Neonatal Medicine, 27(17), 1728-1733. https://doi.org/10.3109/14767058.2013.876622

Haptoglobin phenotype and abnormal uterine artery Doppler in a racially diverse cohort. / Weissgerber, Tracey L.; McGee, Paula L.; Myatt, Leslie; Hauth, John C.; Varner, Michael W.; Wapner, Ronald J.; Thorp, John M.; Mercer, Brian M.; Peaceman, Alan M.; Ramin, Susan M.; Samuels, Philip; Sciscione, Anthony C.; Harper, Margaret; Saade, George; Sorokin, Yoram; Eunice Kennedy Shriver, Natl Inst of Child Hlth and Hum Devmt Matern Fetal Med Units Network.

In: Journal of Maternal-Fetal and Neonatal Medicine, Vol. 27, No. 17, 01.11.2014, p. 1728-1733.

Research output: Contribution to journalArticle

Weissgerber, TL, McGee, PL, Myatt, L, Hauth, JC, Varner, MW, Wapner, RJ, Thorp, JM, Mercer, BM, Peaceman, AM, Ramin, SM, Samuels, P, Sciscione, AC, Harper, M, Saade, G, Sorokin, Y & Eunice Kennedy Shriver, NIOCHAHDMFMUN 2014, 'Haptoglobin phenotype and abnormal uterine artery Doppler in a racially diverse cohort', Journal of Maternal-Fetal and Neonatal Medicine, vol. 27, no. 17, pp. 1728-1733. https://doi.org/10.3109/14767058.2013.876622
Weissgerber, Tracey L. ; McGee, Paula L. ; Myatt, Leslie ; Hauth, John C. ; Varner, Michael W. ; Wapner, Ronald J. ; Thorp, John M. ; Mercer, Brian M. ; Peaceman, Alan M. ; Ramin, Susan M. ; Samuels, Philip ; Sciscione, Anthony C. ; Harper, Margaret ; Saade, George ; Sorokin, Yoram ; Eunice Kennedy Shriver, Natl Inst of Child Hlth and Hum Devmt Matern Fetal Med Units Network. / Haptoglobin phenotype and abnormal uterine artery Doppler in a racially diverse cohort. In: Journal of Maternal-Fetal and Neonatal Medicine. 2014 ; Vol. 27, No. 17. pp. 1728-1733.
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T1 - Haptoglobin phenotype and abnormal uterine artery Doppler in a racially diverse cohort

AU - Weissgerber, Tracey L.

AU - McGee, Paula L.

AU - Myatt, Leslie

AU - Hauth, John C.

AU - Varner, Michael W.

AU - Wapner, Ronald J.

AU - Thorp, John M.

AU - Mercer, Brian M.

AU - Peaceman, Alan M.

AU - Ramin, Susan M.

AU - Samuels, Philip

AU - Sciscione, Anthony C.

AU - Harper, Margaret

AU - Saade, George

AU - Sorokin, Yoram

AU - Eunice Kennedy Shriver, Natl Inst of Child Hlth and Hum Devmt Matern Fetal Med Units Network

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N2 - Objective: The anti-oxidant and proangiogenic protein haptoglobin (Hp) is believed to be important for implantation and pregnancy, although its specific role is not known. The three phenotypes (1-1, 2-1 and 2-2) differ in structure and function. Hp 2-2 is associated with increased vascular stiffness in other populations. We examined whether Hp phenotype is associated with abnormal uterine artery Doppler (UAD) in pregnancy. Methods: We conducted a secondary analysis of a preeclampsia prediction cohort nested within a larger placebo-controlled randomized clinical trial of antioxidants for prevention of preeclampsia. We determined Hp phenotype in 2184 women who completed UAD assessments at 17 weeks gestation. Women with notching were re-evaluated for persistent notching at 24 weeks' gestation. Logistic regression was used to assess differences in UAD indices between phenotype groups. Results: Hp phenotype did not significantly influence the odds of having any notch (p = 0.32), bilateral notches (p = 0.72), or a resistance index (p = 0.28) or pulsatility index (p = 0.67) above the 90th percentile at 17 weeks' gestation. Hp phenotype also did not influence the odds of persistent notching at 24 weeks (p = 0.25). Conclusions: Hp phenotype is not associated with abnormal UAD at 17 weeks' gestation or with persistent notching at 24 weeks.

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