Harnessing mosquito-Wolbachia symbiosis for vector and disease control

Kostas Bourtzis, Stephen L. Dobson, Zhiyong Xi, Jason L. Rasgon, Maurizio Calvitti, Luciano A. Moreira, Hervé C. Bossin, Riccardo Moretti, Luke Anthony Baton, Grant L. Hughes, Patrick Mavingui, Jeremie R L Gilles

Research output: Contribution to journalArticle

124 Citations (Scopus)

Abstract

Mosquito species, members of the genera Aedes, Anopheles and Culex, are the major vectors of human pathogens including protozoa (Plasmodium sp.), filariae and of a variety of viruses (causing dengue, chikungunya, yellow fever, West Nile). There is lack of efficient methods and tools to treat many of the diseases caused by these major human pathogens, since no efficient vaccines or drugs are available; even in malaria where insecticide use and drug therapies have reduced incidence, 219 million cases still occurred in 2010. Therefore efforts are currently focused on the control of vector populations. Insecticides alone are insufficient to control mosquito populations since reduced susceptibility and even resistance is being observed more and more frequently. There is also increased concern about the toxic effects of insecticides on non-target (even beneficial) insect populations, on humans and the environment. During recent years, the role of symbionts in the biology, ecology and evolution of insect species has been well-documented and has led to suggestions that they could potentially be used as tools to control pests and therefore diseases. Wolbachia is perhaps the most renowned insect symbiont, mainly due to its ability to manipulate insect reproduction and to interfere with major human pathogens thus providing new avenues for pest control. We herein present recent achievements in the field of mosquito Wolbachia symbiosis with an emphasis on Aedes albopictus. We also discuss how Wolbachia symbiosis can be harnessed for vector control as well as the potential to combine the sterile insect technique and Wolbachia-based approaches for the enhancement of population suppression programs.

Original languageEnglish (US)
JournalActa Tropica
Volume132
Issue number1
DOIs
StatePublished - 2014
Externally publishedYes

Fingerprint

Wolbachia
Disease Vectors
Symbiosis
vector control
Culicidae
symbiosis
Insects
disease control
Insecticides
insecticides
Pest Control
pest control
symbionts
Aedes
pathogens
Yellow fever virus
insect reproduction
beneficial insects
sterile insect technique
insects

Keywords

  • Aedes albopictus
  • Mosquitoes
  • Sterile insect technique
  • Vector control
  • Wolbachia

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Bourtzis, K., Dobson, S. L., Xi, Z., Rasgon, J. L., Calvitti, M., Moreira, L. A., ... Gilles, J. R. L. (2014). Harnessing mosquito-Wolbachia symbiosis for vector and disease control. Acta Tropica, 132(1). https://doi.org/10.1016/j.actatropica.2013.11.004

Harnessing mosquito-Wolbachia symbiosis for vector and disease control. / Bourtzis, Kostas; Dobson, Stephen L.; Xi, Zhiyong; Rasgon, Jason L.; Calvitti, Maurizio; Moreira, Luciano A.; Bossin, Hervé C.; Moretti, Riccardo; Baton, Luke Anthony; Hughes, Grant L.; Mavingui, Patrick; Gilles, Jeremie R L.

In: Acta Tropica, Vol. 132, No. 1, 2014.

Research output: Contribution to journalArticle

Bourtzis, K, Dobson, SL, Xi, Z, Rasgon, JL, Calvitti, M, Moreira, LA, Bossin, HC, Moretti, R, Baton, LA, Hughes, GL, Mavingui, P & Gilles, JRL 2014, 'Harnessing mosquito-Wolbachia symbiosis for vector and disease control', Acta Tropica, vol. 132, no. 1. https://doi.org/10.1016/j.actatropica.2013.11.004
Bourtzis, Kostas ; Dobson, Stephen L. ; Xi, Zhiyong ; Rasgon, Jason L. ; Calvitti, Maurizio ; Moreira, Luciano A. ; Bossin, Hervé C. ; Moretti, Riccardo ; Baton, Luke Anthony ; Hughes, Grant L. ; Mavingui, Patrick ; Gilles, Jeremie R L. / Harnessing mosquito-Wolbachia symbiosis for vector and disease control. In: Acta Tropica. 2014 ; Vol. 132, No. 1.
@article{f542cadc5d9240ed909bc04cf3929b91,
title = "Harnessing mosquito-Wolbachia symbiosis for vector and disease control",
abstract = "Mosquito species, members of the genera Aedes, Anopheles and Culex, are the major vectors of human pathogens including protozoa (Plasmodium sp.), filariae and of a variety of viruses (causing dengue, chikungunya, yellow fever, West Nile). There is lack of efficient methods and tools to treat many of the diseases caused by these major human pathogens, since no efficient vaccines or drugs are available; even in malaria where insecticide use and drug therapies have reduced incidence, 219 million cases still occurred in 2010. Therefore efforts are currently focused on the control of vector populations. Insecticides alone are insufficient to control mosquito populations since reduced susceptibility and even resistance is being observed more and more frequently. There is also increased concern about the toxic effects of insecticides on non-target (even beneficial) insect populations, on humans and the environment. During recent years, the role of symbionts in the biology, ecology and evolution of insect species has been well-documented and has led to suggestions that they could potentially be used as tools to control pests and therefore diseases. Wolbachia is perhaps the most renowned insect symbiont, mainly due to its ability to manipulate insect reproduction and to interfere with major human pathogens thus providing new avenues for pest control. We herein present recent achievements in the field of mosquito Wolbachia symbiosis with an emphasis on Aedes albopictus. We also discuss how Wolbachia symbiosis can be harnessed for vector control as well as the potential to combine the sterile insect technique and Wolbachia-based approaches for the enhancement of population suppression programs.",
keywords = "Aedes albopictus, Mosquitoes, Sterile insect technique, Vector control, Wolbachia",
author = "Kostas Bourtzis and Dobson, {Stephen L.} and Zhiyong Xi and Rasgon, {Jason L.} and Maurizio Calvitti and Moreira, {Luciano A.} and Bossin, {Herv{\'e} C.} and Riccardo Moretti and Baton, {Luke Anthony} and Hughes, {Grant L.} and Patrick Mavingui and Gilles, {Jeremie R L}",
year = "2014",
doi = "10.1016/j.actatropica.2013.11.004",
language = "English (US)",
volume = "132",
journal = "Acta Tropica",
issn = "0001-706X",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Harnessing mosquito-Wolbachia symbiosis for vector and disease control

AU - Bourtzis, Kostas

AU - Dobson, Stephen L.

AU - Xi, Zhiyong

AU - Rasgon, Jason L.

AU - Calvitti, Maurizio

AU - Moreira, Luciano A.

AU - Bossin, Hervé C.

AU - Moretti, Riccardo

AU - Baton, Luke Anthony

AU - Hughes, Grant L.

AU - Mavingui, Patrick

AU - Gilles, Jeremie R L

PY - 2014

Y1 - 2014

N2 - Mosquito species, members of the genera Aedes, Anopheles and Culex, are the major vectors of human pathogens including protozoa (Plasmodium sp.), filariae and of a variety of viruses (causing dengue, chikungunya, yellow fever, West Nile). There is lack of efficient methods and tools to treat many of the diseases caused by these major human pathogens, since no efficient vaccines or drugs are available; even in malaria where insecticide use and drug therapies have reduced incidence, 219 million cases still occurred in 2010. Therefore efforts are currently focused on the control of vector populations. Insecticides alone are insufficient to control mosquito populations since reduced susceptibility and even resistance is being observed more and more frequently. There is also increased concern about the toxic effects of insecticides on non-target (even beneficial) insect populations, on humans and the environment. During recent years, the role of symbionts in the biology, ecology and evolution of insect species has been well-documented and has led to suggestions that they could potentially be used as tools to control pests and therefore diseases. Wolbachia is perhaps the most renowned insect symbiont, mainly due to its ability to manipulate insect reproduction and to interfere with major human pathogens thus providing new avenues for pest control. We herein present recent achievements in the field of mosquito Wolbachia symbiosis with an emphasis on Aedes albopictus. We also discuss how Wolbachia symbiosis can be harnessed for vector control as well as the potential to combine the sterile insect technique and Wolbachia-based approaches for the enhancement of population suppression programs.

AB - Mosquito species, members of the genera Aedes, Anopheles and Culex, are the major vectors of human pathogens including protozoa (Plasmodium sp.), filariae and of a variety of viruses (causing dengue, chikungunya, yellow fever, West Nile). There is lack of efficient methods and tools to treat many of the diseases caused by these major human pathogens, since no efficient vaccines or drugs are available; even in malaria where insecticide use and drug therapies have reduced incidence, 219 million cases still occurred in 2010. Therefore efforts are currently focused on the control of vector populations. Insecticides alone are insufficient to control mosquito populations since reduced susceptibility and even resistance is being observed more and more frequently. There is also increased concern about the toxic effects of insecticides on non-target (even beneficial) insect populations, on humans and the environment. During recent years, the role of symbionts in the biology, ecology and evolution of insect species has been well-documented and has led to suggestions that they could potentially be used as tools to control pests and therefore diseases. Wolbachia is perhaps the most renowned insect symbiont, mainly due to its ability to manipulate insect reproduction and to interfere with major human pathogens thus providing new avenues for pest control. We herein present recent achievements in the field of mosquito Wolbachia symbiosis with an emphasis on Aedes albopictus. We also discuss how Wolbachia symbiosis can be harnessed for vector control as well as the potential to combine the sterile insect technique and Wolbachia-based approaches for the enhancement of population suppression programs.

KW - Aedes albopictus

KW - Mosquitoes

KW - Sterile insect technique

KW - Vector control

KW - Wolbachia

UR - http://www.scopus.com/inward/record.url?scp=84896542084&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84896542084&partnerID=8YFLogxK

U2 - 10.1016/j.actatropica.2013.11.004

DO - 10.1016/j.actatropica.2013.11.004

M3 - Article

VL - 132

JO - Acta Tropica

JF - Acta Tropica

SN - 0001-706X

IS - 1

ER -