Healing response of the canine prostate to Nd: YAG laser radiation

Mariela Pow-Sang, Eduardo Orihuela, Massoud Motamedi, Jorge Torres, Adekunle Adesokan, Daniel Cowan, Michael M. Warren

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The objective of the study was to characterize the healing response of the canine prostate to laser thermal injury. The study included 20 canine prostates that underwent transurethral laser radiation. The prostates were retrieved 1 hr after laser radiation in 7 dogs (acute group), and from 3 days to 9 weeks in 13 dogs (chronic group). Two distinct features were observed. First, reepithelialization of the prostatic urethra resulted from mobilization of proliferating epithelial cells from acinar and ductal prostatic epithelium into the cavity surface, and not from the edges of the wound at the bladder neck. Squamous cell metaplasia was a prominent feature of reepithelialization. Second, the healing process in the canine prostate was relatively unimpeded. The large glandular component provided abundant germinal epithelial growth, and the absence of stromal elements allowed for complete sloughing of necrotic tissue without residual eschars. Further, the lesions in the chronic group had a tendency to be larger that those in the acute group, suggesting that extended delayed necrosis may occur at deep prostatic tissue layers.

Original languageEnglish (US)
Pages (from-to)287-294
Number of pages8
JournalProstate
Volume28
Issue number5
DOIs
StatePublished - May 1996

Fingerprint

Solid-State Lasers
Canidae
Prostate
Radiation
Lasers
Epithelial Cells
Dogs
Wounds and Injuries
Metaplasia
Urethra
Urinary Bladder
Necrosis
Epithelium
Hot Temperature
Growth

Keywords

  • benign prostatic hyperplasia
  • laser therapy
  • prostate
  • prostatectomy

ASJC Scopus subject areas

  • Urology

Cite this

Healing response of the canine prostate to Nd : YAG laser radiation. / Pow-Sang, Mariela; Orihuela, Eduardo; Motamedi, Massoud; Torres, Jorge; Adesokan, Adekunle; Cowan, Daniel; Warren, Michael M.

In: Prostate, Vol. 28, No. 5, 05.1996, p. 287-294.

Research output: Contribution to journalArticle

Pow-Sang, M, Orihuela, E, Motamedi, M, Torres, J, Adesokan, A, Cowan, D & Warren, MM 1996, 'Healing response of the canine prostate to Nd: YAG laser radiation', Prostate, vol. 28, no. 5, pp. 287-294. https://doi.org/10.1002/(SICI)1097-0045(199605)28:5<287::AID-PROS3>3.0.CO;2-9
Pow-Sang, Mariela ; Orihuela, Eduardo ; Motamedi, Massoud ; Torres, Jorge ; Adesokan, Adekunle ; Cowan, Daniel ; Warren, Michael M. / Healing response of the canine prostate to Nd : YAG laser radiation. In: Prostate. 1996 ; Vol. 28, No. 5. pp. 287-294.
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