Healthcare and economic burden of heart failure with amyloidosis: An insight from National Readmission Database

Shahzad Ahmad, Muddasir Ashraf, Salman Salehin, Syed Mustajab Hasan, Haleema Sadia, Wissam Khalife, Khaled F. Chatila

Research output: Contribution to journalArticlepeer-review


Introduction: We analyzed trends, causes and predictors of 30-days readmission in cardiac amyloidosis and inspected the impact of these readmissions on mortality, morbidity, and utilization of healthcare resources. Methods: Heart Failure with cardiac amyloidosis patients were selected from National readmission Database (NRD) using ICD-10 CM codes. Patients younger than 18 years, elective readmissions, readmissions due to trauma, patients with missing data and December 2018 admissions were excluded. Primary outcome was all-cause 30-day readmissions rate, secondary outcomes were factors associated with 30-days readmissions and their effect on morbidity, mortality, and healthcare resource utilization. Results: Out of 4123 total heart failure with cardiac amyloidosis index admissions in 2018, 3374 patients were included in final analysis. 19.6% were readmitted within 30 days. Readmitted patients were younger, sicker, admitted to small or large hospital. Hypertensive heart and Chronic Kidney Disease (CKD Stage I-IV) with Congestive Heart Failure (CHF), hypertensive heart and CKD (Stage V) or End Stage Renal Disease (ESRD) with CHF, hypertensive heart disease with CHF, acute kidney failure, and sepsis were the most common causes of readmissions. Young age, admission to small and large size hospitals were independent predictors of 30-day readmissions. Readmissions had higher mortality, costed 6.6 extra in hospital days to patients and $16380 per admission to healthcare system. Conclusions: Cardiac amyloidosis readmissions were associated with increased morbidity and mortality of patients and extra burden on the healthcare system. There is a need to identify patients at risk for readmissions to improve patient outcomes and decrease healthcare cost.

Original languageEnglish (US)
Pages (from-to)347-354
Number of pages8
JournalAmerican Journal of the Medical Sciences
Issue number5
StatePublished - Nov 2023


  • Cardiac amyloidosis
  • Heart failure
  • Heart failure with preserved ejection fraction
  • Hospital readmissions

ASJC Scopus subject areas

  • General Medicine


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