Heartland virus infection in hamsters deficient in type I interferon signaling: Protracted disease course ameliorated by favipiravir

Jonna B. Westover, Johanna D. Rigas, Arnaud J. Van Wettere, Rong Li, Brady T. Hickerson, Kie Hoon Jung, Jinxin Miao, Erin S. Reynolds, Bettina L. Conrad, Skot Nielson, Yousuke Furuta, Saravanan Thangamani, Zhongde Wang, Brian B. Gowen

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Heartland virus (HRTV) is an emerging tick-borne virus (Bunyaviridae, Phlebovirus) that has caused sporadic cases of human disease in several central and mid-eastern states of America. Animal models of HRTV disease are needed to gain insights into viral pathogenesis and advancing antiviral drug development. Presence of clinical disease following HRTV challenge in hamsters deficient in STAT2 function underscores the important role played by type I interferon-induced antiviral responses. However, the recovery of most of the infected animals suggests that other mechanisms to control infection and limit disease offer substantial protection. The most prominent disease sign with HRTV infection in STAT2 knockout hamsters was dramatic weight loss with clinical laboratory and histopathology demonstrating acute inflammation in the spleen, lymph node, liver and lung. Finally, we show that HRTV disease in hamsters can be prevented by the use of favipiravir, a promising broad-spectrum antiviral in clinical development for the treatment of influenza.

Original languageEnglish (US)
Pages (from-to)175-183
Number of pages9
JournalVirology
Volume511
DOIs
StatePublished - Nov 1 2017

Fingerprint

Interferon Type I
Virus Diseases
Cricetinae
Antiviral Agents
Viruses
Phlebovirus
Bunyaviridae
Ticks
Infection Control
Human Influenza
Weight Loss
Spleen
Animal Models
Lymph Nodes
Inflammation
Lung
favipiravir
Liver

Keywords

  • Animal model
  • Favipiravir
  • Heartland virus
  • Phlebovirus
  • Severe fever with thrombocytopenia syndrome virus
  • Type I interferon

ASJC Scopus subject areas

  • Virology

Cite this

Westover, J. B., Rigas, J. D., Van Wettere, A. J., Li, R., Hickerson, B. T., Jung, K. H., ... Gowen, B. B. (2017). Heartland virus infection in hamsters deficient in type I interferon signaling: Protracted disease course ameliorated by favipiravir. Virology, 511, 175-183. https://doi.org/10.1016/j.virol.2017.08.004

Heartland virus infection in hamsters deficient in type I interferon signaling : Protracted disease course ameliorated by favipiravir. / Westover, Jonna B.; Rigas, Johanna D.; Van Wettere, Arnaud J.; Li, Rong; Hickerson, Brady T.; Jung, Kie Hoon; Miao, Jinxin; Reynolds, Erin S.; Conrad, Bettina L.; Nielson, Skot; Furuta, Yousuke; Thangamani, Saravanan; Wang, Zhongde; Gowen, Brian B.

In: Virology, Vol. 511, 01.11.2017, p. 175-183.

Research output: Contribution to journalArticle

Westover, JB, Rigas, JD, Van Wettere, AJ, Li, R, Hickerson, BT, Jung, KH, Miao, J, Reynolds, ES, Conrad, BL, Nielson, S, Furuta, Y, Thangamani, S, Wang, Z & Gowen, BB 2017, 'Heartland virus infection in hamsters deficient in type I interferon signaling: Protracted disease course ameliorated by favipiravir', Virology, vol. 511, pp. 175-183. https://doi.org/10.1016/j.virol.2017.08.004
Westover, Jonna B. ; Rigas, Johanna D. ; Van Wettere, Arnaud J. ; Li, Rong ; Hickerson, Brady T. ; Jung, Kie Hoon ; Miao, Jinxin ; Reynolds, Erin S. ; Conrad, Bettina L. ; Nielson, Skot ; Furuta, Yousuke ; Thangamani, Saravanan ; Wang, Zhongde ; Gowen, Brian B. / Heartland virus infection in hamsters deficient in type I interferon signaling : Protracted disease course ameliorated by favipiravir. In: Virology. 2017 ; Vol. 511. pp. 175-183.
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