Heat shock protein 90 is required for sexual and asexual development, virulence, and heat shock response in Fusarium graminearum

Duc Cuong Bui, Yoonji Lee, Jae Yun Lim, Minmin Fu, Jin Cheol Kim, Gyung Ja Choi, Hokyoung Son, Yin Won Lee

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Eukaryotic cells repress global translation and selectively upregulate stress response proteins by altering multiple steps in gene expression. In this study, genome-wide transcriptome analysis of cellular adaptation to thermal stress was performed on the plant pathogenic fungus Fusarium graminearum. The results revealed that profound alterations in gene expression were required for heat shock responses in F. graminearum. Among these proteins, heat shock protein 90 (FgHsp90) was revealed to play a central role in heat shock stress responses in this fungus. FgHsp90 was highly expressed and exclusively localised to nuclei in response to heat stress. Moreover, our comprehensive functional characterisation of FgHsp90 provides clear genetic evidence supporting its crucial roles in the vegetative growth, reproduction, and virulence of F. graminearum. In particular, FgHsp90 performs multiple functions as a transcriptional regulator of conidiation. Our findings provide new insight into the mechanisms underlying adaptation to heat shock and the roles of Hsp90 in fungal development.

Original languageEnglish (US)
Article number28154
JournalScientific reports
Volume6
DOIs
StatePublished - Jun 16 2016
Externally publishedYes

ASJC Scopus subject areas

  • General

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