Heat stress modulated gastrointestinal barrier dysfunction: role of tight junctions and heat shock proteins

Avinash Gupta, Nishant Ranjan Chauhan, Daipayan Chowdhury, Ajeet Singh, Ramesh Chand Meena, Amitabha Chakrabarti, Shashi Bala Singh

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations


Increased environmental temperature exerts a visible impact on an individual’s physiology. At the onset of heat stress, there is an increase in core body temperature which triggers peripheral vasodilation and sweating in an effort to dissipate the elevated body heat. The increase in peripheral circulation however reduces blood flow to the internal organs which are thus adversely affected. In particular, the gastrointestinal (GI) tract gets adversely affected during hyperthermia resulting in loosening of the tight junctions (TJs) that finally leads to higher intestinal permeability. At the cellular level, elevated levels of heat shock proteins (HSPs) induced in response to heat stress mediated cytoprotection by maintaining proper protein folding, releasing survival signals and preserving cytoskeleton integrity. Recent studies have indicated that HSPs play a crucial role in maintaining the localization of TJ proteins. Dietary supplements have also shown to have a positive effect on the maintenance of intestinal TJs. Therefore, it becomes imperative to understand the cellular, molecular and physiological alterations in response to heat stress in GI tract. In the present report, the effect of thermal stress on GI tract has been summarized. Specific role of HSPs along with mitogen activated protein (MAP) kinase signaling pathway in response to hyperthermia has also been discussed.

Original languageEnglish (US)
Pages (from-to)1315-1319
Number of pages5
JournalScandinavian Journal of Gastroenterology
Issue number12
StatePublished - Dec 2 2017
Externally publishedYes


  • Heat stress
  • gastrointestinal tract and MAP kinase
  • heat shock protein
  • hyperthermia
  • tight junction

ASJC Scopus subject areas

  • Gastroenterology


Dive into the research topics of 'Heat stress modulated gastrointestinal barrier dysfunction: role of tight junctions and heat shock proteins'. Together they form a unique fingerprint.

Cite this