Heavy Alcohol Use Among Deceased Donors Does Not Impact Recipient Outcomes After Liver Transplantation

Sumant S. Arora, Khushdeep S. Chahal, Page Axley, Devin E. Eckhoff, Yong Fang Kuo, Sanjaya K. Satapathy, Russell Wiesner, Ashwani K. Singal

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Data on liver transplant (LT) outcomes using deceased donors with heavy drinking (HD) (>2 drinks per day) are scanty.

METHODS: Using the United Network for Organ Sharing database (2002-2014), we examined outcomes after LT in adults comparing deceased HD donors with non-HD (ND) donors.

RESULTS: Of 56 182 first LTs performed in the United States for 10 common indications using deceased donors, 47 882 with available information on alcohol use were analyzed. Of these 47 882 LT recipients, 7298 (15%) were from HD donors, with similar proportion over time (2002-2014, Armitage trend test P = 0.75) and for recipient liver disease etiology (χ P = 0.42). Proportion of liver organ used for LT was lower for HD donors compared with ND donors (63% vs 78%; P < 0.001). Five-year outcomes on first LT comparing 7166 HD donors and 21 498 ND donors matched based on propensity score were similar for liver graft (73.7% vs 73.7%, log rank P = 0.98) and patient survival (77.6% vs 77.0%, P = 0.36). On Cox regression analysis, history of HD in deceased donors did not affect liver graft 1.02 (0.97-1.08) or patient survival 1.03 (0.97-1.09).

CONCLUSIONS: Among LT recipients using select liver grafts, history of HD in deceased donors does not impact outcomes after LT.

Original languageEnglish (US)
Pages (from-to)1864-1869
Number of pages6
JournalTransplantation
Volume102
Issue number11
DOIs
StatePublished - Nov 1 2018

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Liver Transplantation
Alcohols
Tissue Donors
Drinking
Liver
Transplants
Propensity Score
Survival
Liver Diseases
Regression Analysis
Databases

ASJC Scopus subject areas

  • Transplantation

Cite this

Arora, S. S., Chahal, K. S., Axley, P., Eckhoff, D. E., Kuo, Y. F., Satapathy, S. K., ... Singal, A. K. (2018). Heavy Alcohol Use Among Deceased Donors Does Not Impact Recipient Outcomes After Liver Transplantation. Transplantation, 102(11), 1864-1869. https://doi.org/10.1097/TP.0000000000002230

Heavy Alcohol Use Among Deceased Donors Does Not Impact Recipient Outcomes After Liver Transplantation. / Arora, Sumant S.; Chahal, Khushdeep S.; Axley, Page; Eckhoff, Devin E.; Kuo, Yong Fang; Satapathy, Sanjaya K.; Wiesner, Russell; Singal, Ashwani K.

In: Transplantation, Vol. 102, No. 11, 01.11.2018, p. 1864-1869.

Research output: Contribution to journalArticle

Arora, SS, Chahal, KS, Axley, P, Eckhoff, DE, Kuo, YF, Satapathy, SK, Wiesner, R & Singal, AK 2018, 'Heavy Alcohol Use Among Deceased Donors Does Not Impact Recipient Outcomes After Liver Transplantation', Transplantation, vol. 102, no. 11, pp. 1864-1869. https://doi.org/10.1097/TP.0000000000002230
Arora, Sumant S. ; Chahal, Khushdeep S. ; Axley, Page ; Eckhoff, Devin E. ; Kuo, Yong Fang ; Satapathy, Sanjaya K. ; Wiesner, Russell ; Singal, Ashwani K. / Heavy Alcohol Use Among Deceased Donors Does Not Impact Recipient Outcomes After Liver Transplantation. In: Transplantation. 2018 ; Vol. 102, No. 11. pp. 1864-1869.
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AU - Chahal, Khushdeep S.

AU - Axley, Page

AU - Eckhoff, Devin E.

AU - Kuo, Yong Fang

AU - Satapathy, Sanjaya K.

AU - Wiesner, Russell

AU - Singal, Ashwani K.

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N2 - BACKGROUND: Data on liver transplant (LT) outcomes using deceased donors with heavy drinking (HD) (>2 drinks per day) are scanty.METHODS: Using the United Network for Organ Sharing database (2002-2014), we examined outcomes after LT in adults comparing deceased HD donors with non-HD (ND) donors.RESULTS: Of 56 182 first LTs performed in the United States for 10 common indications using deceased donors, 47 882 with available information on alcohol use were analyzed. Of these 47 882 LT recipients, 7298 (15%) were from HD donors, with similar proportion over time (2002-2014, Armitage trend test P = 0.75) and for recipient liver disease etiology (χ P = 0.42). Proportion of liver organ used for LT was lower for HD donors compared with ND donors (63% vs 78%; P < 0.001). Five-year outcomes on first LT comparing 7166 HD donors and 21 498 ND donors matched based on propensity score were similar for liver graft (73.7% vs 73.7%, log rank P = 0.98) and patient survival (77.6% vs 77.0%, P = 0.36). On Cox regression analysis, history of HD in deceased donors did not affect liver graft 1.02 (0.97-1.08) or patient survival 1.03 (0.97-1.09).CONCLUSIONS: Among LT recipients using select liver grafts, history of HD in deceased donors does not impact outcomes after LT.

AB - BACKGROUND: Data on liver transplant (LT) outcomes using deceased donors with heavy drinking (HD) (>2 drinks per day) are scanty.METHODS: Using the United Network for Organ Sharing database (2002-2014), we examined outcomes after LT in adults comparing deceased HD donors with non-HD (ND) donors.RESULTS: Of 56 182 first LTs performed in the United States for 10 common indications using deceased donors, 47 882 with available information on alcohol use were analyzed. Of these 47 882 LT recipients, 7298 (15%) were from HD donors, with similar proportion over time (2002-2014, Armitage trend test P = 0.75) and for recipient liver disease etiology (χ P = 0.42). Proportion of liver organ used for LT was lower for HD donors compared with ND donors (63% vs 78%; P < 0.001). Five-year outcomes on first LT comparing 7166 HD donors and 21 498 ND donors matched based on propensity score were similar for liver graft (73.7% vs 73.7%, log rank P = 0.98) and patient survival (77.6% vs 77.0%, P = 0.36). On Cox regression analysis, history of HD in deceased donors did not affect liver graft 1.02 (0.97-1.08) or patient survival 1.03 (0.97-1.09).CONCLUSIONS: Among LT recipients using select liver grafts, history of HD in deceased donors does not impact outcomes after LT.

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