Helicobacter pylori deregulates T and B cell signaling to trigger immune evasion

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Helicobacter pylori is a prevalent human pathogen that successfully establishes chronic infection, which leads to clinically significant gastric diseases including chronic gastritis, peptic ulcer disease (PUD), and gastric cancer (GC). H. pylori is able to produce a persistent infection due in large part to its ability to hijack the host immune response. The host adaptive immune response is activated to strategically and specifically attack pathogens and normally clears them from the infected host. Since B and T lymphocytes are central mediators of adaptive immunity, in this chapter we review their development and the fundamental mechanisms regulating their activation in order to understand how some of the normal processes are subverted by H. pylori. In this review, we place particular emphasis on the CD4+ T cell responses, their subtypes, and regulatory mechanisms because of the expanding literature in this area related to H. pylori. T lymphocyte differentiation and function are finely orchestrated through a series of cell–cell interactions, which include immune checkpoint receptors. Among the immune checkpoint receptor family, there are some with inhibitory properties that are exploited by tumor cells to facilitate their immune evasion. Gastric epithelial cells (GECs), which act as antigen-presenting cells (APCs) in the gastric mucosa, are induced by H. pylori to express immune checkpoint receptors known to sway T lymphocyte function and thus circumvent effective T effector lymphocyte responses. This chapter reviews these and other mechanisms used by H. pylori to interfere with host immunity in order to persist.

Original languageEnglish (US)
Title of host publicationCurrent Topics in Microbiology and Immunology
PublisherSpringer Verlag
Pages229-265
Number of pages37
DOIs
StatePublished - Jan 1 2019

Publication series

NameCurrent Topics in Microbiology and Immunology
Volume421
ISSN (Print)0070-217X
ISSN (Electronic)2196-9965

Fingerprint

Immune Evasion
Helicobacter pylori
B-Lymphocytes
T-Lymphocytes
Adaptive Immunity
Stomach Diseases
Lymphokines
Gastritis
Antigen-Presenting Cells
Gastric Mucosa
Infection
Peptic Ulcer
Stomach Neoplasms
Immunity
Stomach
Epithelial Cells
Lymphocytes
Neoplasms

Keywords

  • Co-inhibitory receptors
  • Immune checkpoint regulators
  • Immune evasion
  • Lymphocyte development
  • Reprogramming

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology
  • Immunology
  • Microbiology (medical)

Cite this

Reyes, V., & Peniche-Trujillo, A-G. (2019). Helicobacter pylori deregulates T and B cell signaling to trigger immune evasion. In Current Topics in Microbiology and Immunology (pp. 229-265). (Current Topics in Microbiology and Immunology; Vol. 421). Springer Verlag. https://doi.org/10.1007/978-3-030-15138-6_10

Helicobacter pylori deregulates T and B cell signaling to trigger immune evasion. / Reyes, Victor; Peniche-Trujillo, Alex-Giovanny.

Current Topics in Microbiology and Immunology. Springer Verlag, 2019. p. 229-265 (Current Topics in Microbiology and Immunology; Vol. 421).

Research output: Chapter in Book/Report/Conference proceedingChapter

Reyes, V & Peniche-Trujillo, A-G 2019, Helicobacter pylori deregulates T and B cell signaling to trigger immune evasion. in Current Topics in Microbiology and Immunology. Current Topics in Microbiology and Immunology, vol. 421, Springer Verlag, pp. 229-265. https://doi.org/10.1007/978-3-030-15138-6_10
Reyes V, Peniche-Trujillo A-G. Helicobacter pylori deregulates T and B cell signaling to trigger immune evasion. In Current Topics in Microbiology and Immunology. Springer Verlag. 2019. p. 229-265. (Current Topics in Microbiology and Immunology). https://doi.org/10.1007/978-3-030-15138-6_10
Reyes, Victor ; Peniche-Trujillo, Alex-Giovanny. / Helicobacter pylori deregulates T and B cell signaling to trigger immune evasion. Current Topics in Microbiology and Immunology. Springer Verlag, 2019. pp. 229-265 (Current Topics in Microbiology and Immunology).
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