Hemodynamic effects of anthrax toxins in the rabbit model and the cardiac pathology induced by lethal toxin

William Lawrence, Jeffrey R. Marshall, Diana L. Zavala, Lori E. Weaver, Wallace B. Baze, Scott T. Moen, Elbert B. Whorton, Randy L. Gourley, Johnny Peterson

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Anthrax lethal toxin (LeTx) and edema toxin (EdTx) have been shown to alter hemodynamics in the rodent model, while LeTx primarily is reported to induce extensive tissue pathology. However, the rodent model has limitations when used for comparison to higher organisms such as humans. The rabbit model, on the other hand, has gained recognition as a useful model for studying anthrax infection and its pathophysiological effects. In this study, we assessed the hemodynamic effects of lethal toxin (LeTx) and edema toxin (EdTx) in the rabbit model using physiologically relevant amounts of the toxins. Moreover, we further examine the pathological effects of LeTx on cardiac tissue. We intravenously injected Dutch-belted rabbits with either low-dose and high-dose recombinant LeTx or a single dose of EdTx. The animals' heart rate and mean arterial pressure were continuously monitored via telemetry until either 48 or 72 h post-challenge. Additional animals challenged with LeTx were used for cardiac troponin I (cTnI) quantitation, cardiac histopathology, and echocardiography. LeTx depressed heart.

Original languageEnglish (US)
Pages (from-to)721-736
Number of pages16
JournalToxins
Volume3
Issue number6
DOIs
StatePublished - Jun 2011

Fingerprint

Hemodynamics
Pathology
Edema
Rabbits
Rodentia
Anthrax
Telemetry
Troponin I
Animals
Echocardiography
Tissue
Arterial Pressure
Heart Rate
Telemetering
Infection
anthrax toxin

Keywords

  • Anthrax
  • Cardiac
  • Lethal toxin
  • Rabbit model
  • References

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Hemodynamic effects of anthrax toxins in the rabbit model and the cardiac pathology induced by lethal toxin. / Lawrence, William; Marshall, Jeffrey R.; Zavala, Diana L.; Weaver, Lori E.; Baze, Wallace B.; Moen, Scott T.; Whorton, Elbert B.; Gourley, Randy L.; Peterson, Johnny.

In: Toxins, Vol. 3, No. 6, 06.2011, p. 721-736.

Research output: Contribution to journalArticle

Lawrence, W, Marshall, JR, Zavala, DL, Weaver, LE, Baze, WB, Moen, ST, Whorton, EB, Gourley, RL & Peterson, J 2011, 'Hemodynamic effects of anthrax toxins in the rabbit model and the cardiac pathology induced by lethal toxin', Toxins, vol. 3, no. 6, pp. 721-736. https://doi.org/10.3390/toxins3060721
Lawrence, William ; Marshall, Jeffrey R. ; Zavala, Diana L. ; Weaver, Lori E. ; Baze, Wallace B. ; Moen, Scott T. ; Whorton, Elbert B. ; Gourley, Randy L. ; Peterson, Johnny. / Hemodynamic effects of anthrax toxins in the rabbit model and the cardiac pathology induced by lethal toxin. In: Toxins. 2011 ; Vol. 3, No. 6. pp. 721-736.
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