Hemodynamics of small aneurysm pairs at the internal carotid artery

Liang Der Jou, Hesham Morsi, Hashem Shaltoni, Michel E. Mawad

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Cerebral aneurysms carry significant risks because rupture-related subarachnoid hemorrhage leads to serious and often fatal consequences. The rupture risk increases considerably for multiple aneurysms. Multiple aneurysms can grow from the same location of an artery, and the interaction between these aneurysms raises the rupture risk even higher. Four aneurysm pair cases at the internal carotid artery are investigated for their hemodynamic behaviors using patient-specific modeling. For each case, aneurysms are separated from the parent artery and three models are reconstructed, one with two aneurysms and the other two models with only one of the two aneurysms. Results show that the relative anatomic location of one aneurysm to the other may determine the hemodynamic environment of an aneurysm. The presence of a proximal aneurysm reduces the intra-aneurysmal flow into the distal aneurysm; the proximal aneurysm and larger aneurysm have a greater area under low wall shear stress. The average intra-aneurysmal inflow ratio ranges from 16% to 41%, and reduction of the inflow ratio by an aneurysm pair varies from 6% to 15%. The maximum wall shear stress increases for serial aneurysms, but decreases for parallel aneurysms. Interaction between parallel aneurysms is not significant; however, the proximal aneurysm in serial aneurysms may be subject to a greater rupture risk.

Original languageEnglish (US)
Pages (from-to)1454-1461
Number of pages8
JournalMedical Engineering and Physics
Volume34
Issue number10
DOIs
StatePublished - Dec 1 2012
Externally publishedYes

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Hemodynamics
Internal Carotid Artery
Aneurysm
Shear stress
Rupture
Arteries
Intracranial Aneurysm
Subarachnoid Hemorrhage

Keywords

  • Aneurysms
  • Cerebrovascular disease
  • Hemodynamics
  • Wall shear stress

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biophysics

Cite this

Hemodynamics of small aneurysm pairs at the internal carotid artery. / Jou, Liang Der; Morsi, Hesham; Shaltoni, Hashem; Mawad, Michel E.

In: Medical Engineering and Physics, Vol. 34, No. 10, 01.12.2012, p. 1454-1461.

Research output: Contribution to journalArticle

Jou, Liang Der ; Morsi, Hesham ; Shaltoni, Hashem ; Mawad, Michel E. / Hemodynamics of small aneurysm pairs at the internal carotid artery. In: Medical Engineering and Physics. 2012 ; Vol. 34, No. 10. pp. 1454-1461.
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