Hemoglobin A2 levels in health and various hematologic disorders

J. B. Alperin, P. A. Dow, M. B. Petteway

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Using a method involving elution of hemoglobin bands from cellulose acetate strips following electrophoresis of hemolysates, hemoglobin A2 (Hb A2) was quantitated in bloods from 300 healthy individuals and 904 patients. The percentage of Hb A2 was elevated in β thalassemia heterozygotes and some patients who had megaloblastic anemia. In the latter, the highest Hb A2 levels were observed in patients with the most severe anemia. Low Hb A2 percentages were found in iron deficiency anemia, hereditary persistance of fetal hemoglobin, and Hb H disease. In iron deficiency anemia, the lowest levels of Hb A2 were observed in association with the most severe anemia. Iron and folate deficiency each suppressed Hb A2 levels in β thalassemia heterozygotes; however, vitamin B12 deficiency did not alter the percentage of Hb A2 in thalassemia. Malignant tumors, renal and hepatic insufficiency, chronic infections and inflammation, hemolytic disease, lead poisoning, aplastic anemia, leukemia, myelofibrosis, and hypothyroidism did not change Hb A2 levels. The pathogenesis of altered Hb A2 levels and their clinical significance in various diseases are discussed.

Original languageEnglish (US)
Pages (from-to)219-226
Number of pages8
JournalAmerican Journal of Clinical Pathology
Volume67
Issue number3
StatePublished - 1977

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Hemoglobin A2
Health Status
Thalassemia
Iron-Deficiency Anemias
Heterozygote
Anemia
Megaloblastic Anemia
Hepatic Insufficiency
Vitamin B 12 Deficiency
alpha-Thalassemia
Fetal Hemoglobin
Lead Poisoning
Primary Myelofibrosis
Aplastic Anemia
Hypothyroidism
Folic Acid
Renal Insufficiency
Electrophoresis
Leukemia
Hemoglobins

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Alperin, J. B., Dow, P. A., & Petteway, M. B. (1977). Hemoglobin A2 levels in health and various hematologic disorders. American Journal of Clinical Pathology, 67(3), 219-226.

Hemoglobin A2 levels in health and various hematologic disorders. / Alperin, J. B.; Dow, P. A.; Petteway, M. B.

In: American Journal of Clinical Pathology, Vol. 67, No. 3, 1977, p. 219-226.

Research output: Contribution to journalArticle

Alperin, JB, Dow, PA & Petteway, MB 1977, 'Hemoglobin A2 levels in health and various hematologic disorders', American Journal of Clinical Pathology, vol. 67, no. 3, pp. 219-226.
Alperin, J. B. ; Dow, P. A. ; Petteway, M. B. / Hemoglobin A2 levels in health and various hematologic disorders. In: American Journal of Clinical Pathology. 1977 ; Vol. 67, No. 3. pp. 219-226.
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