Hemoglobin I in an American Negro family

Structural and hematologic studies

Rose G. Schneider, Jack B. Alperin, Dennis Beale, Hermann Lehmann

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

An American Negro family is described, in which the mother and two children have hemoglobin I trait, each with 24 to 28 per cent hemoglobin I. In all three of these subjects, target cells comprise about 10 per cent of the erythrocyte population. No other hematologic abnormality was found in the parents and their five examined children. In tests with 4 per cent sodium metabisulfite, changes resembling sickling occurred in the erythrocytes of all seven members of the family and also in five unrelated individuals who are homozygous for hemoglobin A. On structural analysis, the substitution in this sample of hemoglobin I is α16 lys → glu, as was previously found in one other sample of hemoglobin I (I Philadelphia).

Original languageEnglish (US)
Pages (from-to)940-946
Number of pages7
JournalThe Journal of Laboratory and Clinical Medicine
Volume68
Issue number6
StatePublished - Dec 1966
Externally publishedYes

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Hemoglobins
Erythrocytes
Hemoglobin A
Structural analysis
Substitution reactions
Parents
Mothers
Population

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medicine(all)

Cite this

Schneider, R. G., Alperin, J. B., Beale, D., & Lehmann, H. (1966). Hemoglobin I in an American Negro family: Structural and hematologic studies. The Journal of Laboratory and Clinical Medicine, 68(6), 940-946.

Hemoglobin I in an American Negro family : Structural and hematologic studies. / Schneider, Rose G.; Alperin, Jack B.; Beale, Dennis; Lehmann, Hermann.

In: The Journal of Laboratory and Clinical Medicine, Vol. 68, No. 6, 12.1966, p. 940-946.

Research output: Contribution to journalArticle

Schneider, RG, Alperin, JB, Beale, D & Lehmann, H 1966, 'Hemoglobin I in an American Negro family: Structural and hematologic studies', The Journal of Laboratory and Clinical Medicine, vol. 68, no. 6, pp. 940-946.
Schneider, Rose G. ; Alperin, Jack B. ; Beale, Dennis ; Lehmann, Hermann. / Hemoglobin I in an American Negro family : Structural and hematologic studies. In: The Journal of Laboratory and Clinical Medicine. 1966 ; Vol. 68, No. 6. pp. 940-946.
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