Structural analysis of hemoglobin P reveals a substitution of the histidine by an arginine residue at β 117, in the helical position G 19. In both subjects with Hgb. P trait there are slight morphologic abnormalities of the erythrocytes-hypochromia, anisopoikilocytosis, and targeting. These may reflect molecular instability due to a disturbance of the pattern of hydrogen bonds in the α1β1 region of the molecule.
|Original language||English (US)|
|Number of pages||7|
|Journal||The Journal of Laboratory and Clinical Medicine|
|State||Published - Apr 1 1969|
ASJC Scopus subject areas
- Pathology and Forensic Medicine