Hemorrhagic hypotension impairs endothelium-dependent relaxations in the renal artery of the cat

Csaba Szabo, M. Farago, I. Horvath, Z. Lohinai, A. G B Kovach

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

The effect of hemorrhagic shock on the vasodilatory responses of the feline renal artery was studied in vitro. In sodium pentobarbital anaesthetized cats, a steady level of hypotension (50 mm Hg) was reached by bleeding into a reservoir and maintained at this level by further bleeding or autotransfusion for 2 hr (shock). One to 3 mm long rings of the arteries (from control and shocked animals) were suspended for isometric tension recording in organ chambers filled with modified Krebs-Henseleit solution, aerated with 95% O2-5% CO2 at 37°C. The experiments were performed in the presence of indomethacin and propranolol to inhibit cyclooxygenase activity and beta-adrenoceptors, respectively. Endothelium-dependent relaxations induced by acetylcholine and ATP were significantly inhibited in the vessels after hemorrhagic shock. In contrast, endothelium-independent vasodilation induced by adenosine remained unchanged after this shock state. The present results suggest a marked and selective impairment of the endothelial function of the renal artery of hemorrhagic shock. This alteration of the renovascular reactivity might play an important role in the development of vasoconstriction in the renal vasculature during and after this hemorrhagic shock state.

Original languageEnglish (US)
Pages (from-to)238-241
Number of pages4
JournalCirculatory Shock
Volume36
Issue number3
StatePublished - 1992
Externally publishedYes

Fingerprint

Hemorrhagic Shock
Renal Artery
Hypotension
Endothelium
Cats
Shock
Hemorrhage
Autologous Blood Transfusions
Felidae
Pentobarbital
Prostaglandin-Endoperoxide Synthases
Vasoconstriction
Vasodilation
Propranolol
Indomethacin
Adenosine
Adrenergic Receptors
Acetylcholine
Arteries
Adenosine Triphosphate

Keywords

  • acetylcholine
  • adenosine
  • ATP
  • EDRF
  • hemorrhagic shock
  • kidney

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Szabo, C., Farago, M., Horvath, I., Lohinai, Z., & Kovach, A. G. B. (1992). Hemorrhagic hypotension impairs endothelium-dependent relaxations in the renal artery of the cat. Circulatory Shock, 36(3), 238-241.

Hemorrhagic hypotension impairs endothelium-dependent relaxations in the renal artery of the cat. / Szabo, Csaba; Farago, M.; Horvath, I.; Lohinai, Z.; Kovach, A. G B.

In: Circulatory Shock, Vol. 36, No. 3, 1992, p. 238-241.

Research output: Contribution to journalArticle

Szabo, C, Farago, M, Horvath, I, Lohinai, Z & Kovach, AGB 1992, 'Hemorrhagic hypotension impairs endothelium-dependent relaxations in the renal artery of the cat', Circulatory Shock, vol. 36, no. 3, pp. 238-241.
Szabo, Csaba ; Farago, M. ; Horvath, I. ; Lohinai, Z. ; Kovach, A. G B. / Hemorrhagic hypotension impairs endothelium-dependent relaxations in the renal artery of the cat. In: Circulatory Shock. 1992 ; Vol. 36, No. 3. pp. 238-241.
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