Hepatic hemangioendothelioma presenting as sudden unexpected death in infancy

A case report

Johan Dempers, Shabbir Ahmed Wadee, Theonia Boyd, Colleen Wright, Hein J. Odendaal, Mary Ann Sens, Larry Burd, Kimberly A. Dukes, Amy Elliott, William P. Fifer, Rebecca Folkerth, Gary Hankins, Dale Herald, Hannah C. Kinney, Michael M. Myers, Caroline Signore, Lisa M. Sullivan, Marian Willinger

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The classification of an unexpected infant death as suddeninfant death syndrome (SIDS) depends upon a complete autopsy, death scene investigation, and review of medical history to exclude known causes of death. Death from occult neoplastic disease in infancy is extremely rare but is within the broad differential diagnosis of SIDS. We report the sudden and unexpected death of a 1-month-old infant from a hepatic (infantile) hemangioendothelioma. The physiologic mechanism of death was likely cardiac failure induced by the circulatory demands of this large vascular tumor and respiratory compromise from diaphragmatic thoracic incursion. The clinical progression and pathology of these relatively common tumors of infant livers are extremely variable. This case dramatically illustrates the potential for fatal outcome of this tumor, as well as the need for autopsy to determine the cause of sudden and unexpected death in an infant.

Original languageEnglish (US)
Pages (from-to)71-74
Number of pages4
JournalPediatric and Developmental Pathology
Volume14
Issue number1
DOIs
StatePublished - Jan 2011
Externally publishedYes

Fingerprint

Hemangioendothelioma
Sudden Death
Liver
Autopsy
Neoplasms
Clinical Pathology
Fatal Outcome
Blood Vessels
Cause of Death
Differential Diagnosis
Thorax
Heart Failure

Keywords

  • Autopsy
  • Death scene investigation
  • Heart failure
  • Hepatic neoplasms
  • Sudden unexplained death in infancy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pathology and Forensic Medicine

Cite this

Dempers, J., Wadee, S. A., Boyd, T., Wright, C., Odendaal, H. J., Sens, M. A., ... Willinger, M. (2011). Hepatic hemangioendothelioma presenting as sudden unexpected death in infancy: A case report. Pediatric and Developmental Pathology, 14(1), 71-74. https://doi.org/10.2350/10-01-0776-CR.1

Hepatic hemangioendothelioma presenting as sudden unexpected death in infancy : A case report. / Dempers, Johan; Wadee, Shabbir Ahmed; Boyd, Theonia; Wright, Colleen; Odendaal, Hein J.; Sens, Mary Ann; Burd, Larry; Dukes, Kimberly A.; Elliott, Amy; Fifer, William P.; Folkerth, Rebecca; Hankins, Gary; Herald, Dale; Kinney, Hannah C.; Myers, Michael M.; Signore, Caroline; Sullivan, Lisa M.; Willinger, Marian.

In: Pediatric and Developmental Pathology, Vol. 14, No. 1, 01.2011, p. 71-74.

Research output: Contribution to journalArticle

Dempers, J, Wadee, SA, Boyd, T, Wright, C, Odendaal, HJ, Sens, MA, Burd, L, Dukes, KA, Elliott, A, Fifer, WP, Folkerth, R, Hankins, G, Herald, D, Kinney, HC, Myers, MM, Signore, C, Sullivan, LM & Willinger, M 2011, 'Hepatic hemangioendothelioma presenting as sudden unexpected death in infancy: A case report', Pediatric and Developmental Pathology, vol. 14, no. 1, pp. 71-74. https://doi.org/10.2350/10-01-0776-CR.1
Dempers, Johan ; Wadee, Shabbir Ahmed ; Boyd, Theonia ; Wright, Colleen ; Odendaal, Hein J. ; Sens, Mary Ann ; Burd, Larry ; Dukes, Kimberly A. ; Elliott, Amy ; Fifer, William P. ; Folkerth, Rebecca ; Hankins, Gary ; Herald, Dale ; Kinney, Hannah C. ; Myers, Michael M. ; Signore, Caroline ; Sullivan, Lisa M. ; Willinger, Marian. / Hepatic hemangioendothelioma presenting as sudden unexpected death in infancy : A case report. In: Pediatric and Developmental Pathology. 2011 ; Vol. 14, No. 1. pp. 71-74.
@article{d18dbe638721486b9e80cb8e9ecad3be,
title = "Hepatic hemangioendothelioma presenting as sudden unexpected death in infancy: A case report",
abstract = "The classification of an unexpected infant death as suddeninfant death syndrome (SIDS) depends upon a complete autopsy, death scene investigation, and review of medical history to exclude known causes of death. Death from occult neoplastic disease in infancy is extremely rare but is within the broad differential diagnosis of SIDS. We report the sudden and unexpected death of a 1-month-old infant from a hepatic (infantile) hemangioendothelioma. The physiologic mechanism of death was likely cardiac failure induced by the circulatory demands of this large vascular tumor and respiratory compromise from diaphragmatic thoracic incursion. The clinical progression and pathology of these relatively common tumors of infant livers are extremely variable. This case dramatically illustrates the potential for fatal outcome of this tumor, as well as the need for autopsy to determine the cause of sudden and unexpected death in an infant.",
keywords = "Autopsy, Death scene investigation, Heart failure, Hepatic neoplasms, Sudden unexplained death in infancy",
author = "Johan Dempers and Wadee, {Shabbir Ahmed} and Theonia Boyd and Colleen Wright and Odendaal, {Hein J.} and Sens, {Mary Ann} and Larry Burd and Dukes, {Kimberly A.} and Amy Elliott and Fifer, {William P.} and Rebecca Folkerth and Gary Hankins and Dale Herald and Kinney, {Hannah C.} and Myers, {Michael M.} and Caroline Signore and Sullivan, {Lisa M.} and Marian Willinger",
year = "2011",
month = "1",
doi = "10.2350/10-01-0776-CR.1",
language = "English (US)",
volume = "14",
pages = "71--74",
journal = "Pediatric and Developmental Pathology",
issn = "1093-5266",
publisher = "Society for Pediatric Pathology",
number = "1",

}

TY - JOUR

T1 - Hepatic hemangioendothelioma presenting as sudden unexpected death in infancy

T2 - A case report

AU - Dempers, Johan

AU - Wadee, Shabbir Ahmed

AU - Boyd, Theonia

AU - Wright, Colleen

AU - Odendaal, Hein J.

AU - Sens, Mary Ann

AU - Burd, Larry

AU - Dukes, Kimberly A.

AU - Elliott, Amy

AU - Fifer, William P.

AU - Folkerth, Rebecca

AU - Hankins, Gary

AU - Herald, Dale

AU - Kinney, Hannah C.

AU - Myers, Michael M.

AU - Signore, Caroline

AU - Sullivan, Lisa M.

AU - Willinger, Marian

PY - 2011/1

Y1 - 2011/1

N2 - The classification of an unexpected infant death as suddeninfant death syndrome (SIDS) depends upon a complete autopsy, death scene investigation, and review of medical history to exclude known causes of death. Death from occult neoplastic disease in infancy is extremely rare but is within the broad differential diagnosis of SIDS. We report the sudden and unexpected death of a 1-month-old infant from a hepatic (infantile) hemangioendothelioma. The physiologic mechanism of death was likely cardiac failure induced by the circulatory demands of this large vascular tumor and respiratory compromise from diaphragmatic thoracic incursion. The clinical progression and pathology of these relatively common tumors of infant livers are extremely variable. This case dramatically illustrates the potential for fatal outcome of this tumor, as well as the need for autopsy to determine the cause of sudden and unexpected death in an infant.

AB - The classification of an unexpected infant death as suddeninfant death syndrome (SIDS) depends upon a complete autopsy, death scene investigation, and review of medical history to exclude known causes of death. Death from occult neoplastic disease in infancy is extremely rare but is within the broad differential diagnosis of SIDS. We report the sudden and unexpected death of a 1-month-old infant from a hepatic (infantile) hemangioendothelioma. The physiologic mechanism of death was likely cardiac failure induced by the circulatory demands of this large vascular tumor and respiratory compromise from diaphragmatic thoracic incursion. The clinical progression and pathology of these relatively common tumors of infant livers are extremely variable. This case dramatically illustrates the potential for fatal outcome of this tumor, as well as the need for autopsy to determine the cause of sudden and unexpected death in an infant.

KW - Autopsy

KW - Death scene investigation

KW - Heart failure

KW - Hepatic neoplasms

KW - Sudden unexplained death in infancy

UR - http://www.scopus.com/inward/record.url?scp=79955044214&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79955044214&partnerID=8YFLogxK

U2 - 10.2350/10-01-0776-CR.1

DO - 10.2350/10-01-0776-CR.1

M3 - Article

VL - 14

SP - 71

EP - 74

JO - Pediatric and Developmental Pathology

JF - Pediatric and Developmental Pathology

SN - 1093-5266

IS - 1

ER -