Hepatic progenitors and strategies for liver cell therapies

R. Susick, N. Moss, H. Kubota, E. Lecluyse, G. Hamilton, T. Luntz, J. Ludlow, Jeffrey Fair, D. Gerber, K. Bergstrand, J. White, A. Bruce, O. Drury, S. Gupta, L. M. Reid

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Liver cell therapies, including liver cell transplantation and bioartificial livers, are being developed as alternatives to whole liver transplantation for some patients with severe liver dysfunction. Hepatic progenitors are proposed as ideal cells for use in these liver cell therapies given their ability to expand extensively, differentiate into all mature liver cells, have minimal immunogenicity, be cryopreservable, and reconstitute liver tissue when transplanted. We summarize our ongoing efforts to develop clinical programs of hepatic progenitor cell therapies with a focus on hepatic stem cell biology and strategies that have emerged in analyzing that biology.

Original languageEnglish (US)
Pages (from-to)398-419
Number of pages22
JournalAnnals of the New York Academy of Sciences
Volume944
StatePublished - 2001
Externally publishedYes

Fingerprint

Cell- and Tissue-Based Therapy
Liver
Liver Transplantation
Hepatocytes
Stem Cells
Artificial Liver
Cell Transplantation
Cytology
Cell Biology
Liver Diseases
Therapy
Cells
Stem cells
Tissue

Keywords

  • Hepatic progenitors
  • Liver
  • Liver cell therapies
  • Liver transplantation
  • Stem cells

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Susick, R., Moss, N., Kubota, H., Lecluyse, E., Hamilton, G., Luntz, T., ... Reid, L. M. (2001). Hepatic progenitors and strategies for liver cell therapies. Annals of the New York Academy of Sciences, 944, 398-419.

Hepatic progenitors and strategies for liver cell therapies. / Susick, R.; Moss, N.; Kubota, H.; Lecluyse, E.; Hamilton, G.; Luntz, T.; Ludlow, J.; Fair, Jeffrey; Gerber, D.; Bergstrand, K.; White, J.; Bruce, A.; Drury, O.; Gupta, S.; Reid, L. M.

In: Annals of the New York Academy of Sciences, Vol. 944, 2001, p. 398-419.

Research output: Contribution to journalArticle

Susick, R, Moss, N, Kubota, H, Lecluyse, E, Hamilton, G, Luntz, T, Ludlow, J, Fair, J, Gerber, D, Bergstrand, K, White, J, Bruce, A, Drury, O, Gupta, S & Reid, LM 2001, 'Hepatic progenitors and strategies for liver cell therapies', Annals of the New York Academy of Sciences, vol. 944, pp. 398-419.
Susick R, Moss N, Kubota H, Lecluyse E, Hamilton G, Luntz T et al. Hepatic progenitors and strategies for liver cell therapies. Annals of the New York Academy of Sciences. 2001;944:398-419.
Susick, R. ; Moss, N. ; Kubota, H. ; Lecluyse, E. ; Hamilton, G. ; Luntz, T. ; Ludlow, J. ; Fair, Jeffrey ; Gerber, D. ; Bergstrand, K. ; White, J. ; Bruce, A. ; Drury, O. ; Gupta, S. ; Reid, L. M. / Hepatic progenitors and strategies for liver cell therapies. In: Annals of the New York Academy of Sciences. 2001 ; Vol. 944. pp. 398-419.
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AU - Ludlow, J.

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