Hepatic progenitors and strategies for liver cell therapies

R. Susick, N. Moss, H. Kubota, E. Lecluyse, G. Hamilton, T. Luntz, J. Ludlow, J. Fair, D. Gerber, K. Bergstrand, J. White, A. Bruce, O. Drury, S. Gupta, L. M. Reid

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

Liver cell therapies, including liver cell transplantation and bioartificial livers, are being developed as alternatives to whole liver transplantation for some patients with severe liver dysfunction. Hepatic progenitors are proposed as ideal cells for use in these liver cell therapies given their ability to expand extensively, differentiate into all mature liver cells, have minimal immunogenicity, be cryopreservable, and reconstitute liver tissue when transplanted. We summarize our ongoing efforts to develop clinical programs of hepatic progenitor cell therapies with a focus on hepatic stem cell biology and strategies that have emerged in analyzing that biology.

Original languageEnglish (US)
Pages (from-to)398-419
Number of pages22
JournalAnnals of the New York Academy of Sciences
Volume944
StatePublished - Jan 1 2001
Externally publishedYes

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Keywords

  • Hepatic progenitors
  • Liver
  • Liver cell therapies
  • Liver transplantation
  • Stem cells

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

Susick, R., Moss, N., Kubota, H., Lecluyse, E., Hamilton, G., Luntz, T., Ludlow, J., Fair, J., Gerber, D., Bergstrand, K., White, J., Bruce, A., Drury, O., Gupta, S., & Reid, L. M. (2001). Hepatic progenitors and strategies for liver cell therapies. Annals of the New York Academy of Sciences, 944, 398-419.