Hepatic progenitors and strategies for liver cell therapies

R. Susick, N. Moss, H. Kubota, E. Lecluyse, G. Hamilton, T. Luntz, J. Ludlow, J. Fair, D. Gerber, K. Bergstrand, J. White, A. Bruce, O. Drury, S. Gupta, L. M. Reid

Research output: Contribution to journalArticlepeer-review

58 Scopus citations


Liver cell therapies, including liver cell transplantation and bioartificial livers, are being developed as alternatives to whole liver transplantation for some patients with severe liver dysfunction. Hepatic progenitors are proposed as ideal cells for use in these liver cell therapies given their ability to expand extensively, differentiate into all mature liver cells, have minimal immunogenicity, be cryopreservable, and reconstitute liver tissue when transplanted. We summarize our ongoing efforts to develop clinical programs of hepatic progenitor cell therapies with a focus on hepatic stem cell biology and strategies that have emerged in analyzing that biology.

Original languageEnglish (US)
Pages (from-to)398-419
Number of pages22
JournalAnnals of the New York Academy of Sciences
StatePublished - 2001
Externally publishedYes


  • Hepatic progenitors
  • Liver
  • Liver cell therapies
  • Liver transplantation
  • Stem cells

ASJC Scopus subject areas

  • General Neuroscience
  • General Biochemistry, Genetics and Molecular Biology
  • History and Philosophy of Science


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