Hepatitis B antigen in infants born to mothers with chronic hepatitis B antigenemia in Taiwan.

Karl Anderson, C. E. Stevens, J. J. Tsuei, W. C. Lee, S. C. Sun, P. Beasley

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Hepatitis B antigen (HB Ag) was detected by complement fixation (CF) in serum samples of 7.5% of 1,106 pregnant Chinese women tested in Taipei, Taiwan. HG Ag persisted in all but one of 42 women followed for 1 to 18 months (average, nine months) after delivery, and 27 of the 43 infants (63%) born to those women became antigen-positive. Persistance of the antigen was more common than transient or intermittent antigenemia. Twelve had antigenemia when first tested, while 15 later developed antigenemia, usually during the first six months of life. Only one infant developed antibody to HG Ag (anti-HB Ag), and this occurred after transient antigenemia. The HB Ag was found in two of 32 (6%) fathers, and in 18 of 27 (67%) older siblings. The antigen was more common among siblings of antigen-positive than among those of antigen-negative infants. These findings demonstrate that in Taiwan, infants born to mothers who are asymptomatic carriers of HB Ag commonly become infected by heaptitis B (HB) virus. Exposure of infants near the time of birth may be important maintaining the high, chronic HB Ag carrier rate in Taiwan.

Original languageEnglish (US)
Pages (from-to)1389-1392
Number of pages4
JournalAmerican Journal of Diseases of Children
Volume129
Issue number12
StatePublished - Dec 1975
Externally publishedYes

Fingerprint

Hepatitis B Antigens
Chronic Hepatitis B
Taiwan
Mothers
Antigens
Siblings
Hepatitis B Antibodies
Cercopithecine Herpesvirus 1
Fathers
Pregnant Women
Parturition
Antibodies
Serum

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Anderson, K., Stevens, C. E., Tsuei, J. J., Lee, W. C., Sun, S. C., & Beasley, P. (1975). Hepatitis B antigen in infants born to mothers with chronic hepatitis B antigenemia in Taiwan. American Journal of Diseases of Children, 129(12), 1389-1392.

Hepatitis B antigen in infants born to mothers with chronic hepatitis B antigenemia in Taiwan. / Anderson, Karl; Stevens, C. E.; Tsuei, J. J.; Lee, W. C.; Sun, S. C.; Beasley, P.

In: American Journal of Diseases of Children, Vol. 129, No. 12, 12.1975, p. 1389-1392.

Research output: Contribution to journalArticle

Anderson, K, Stevens, CE, Tsuei, JJ, Lee, WC, Sun, SC & Beasley, P 1975, 'Hepatitis B antigen in infants born to mothers with chronic hepatitis B antigenemia in Taiwan.', American Journal of Diseases of Children, vol. 129, no. 12, pp. 1389-1392.
Anderson, Karl ; Stevens, C. E. ; Tsuei, J. J. ; Lee, W. C. ; Sun, S. C. ; Beasley, P. / Hepatitis B antigen in infants born to mothers with chronic hepatitis B antigenemia in Taiwan. In: American Journal of Diseases of Children. 1975 ; Vol. 129, No. 12. pp. 1389-1392.
@article{e12613d6f22d421d99fd2a2374d48629,
title = "Hepatitis B antigen in infants born to mothers with chronic hepatitis B antigenemia in Taiwan.",
abstract = "Hepatitis B antigen (HB Ag) was detected by complement fixation (CF) in serum samples of 7.5{\%} of 1,106 pregnant Chinese women tested in Taipei, Taiwan. HG Ag persisted in all but one of 42 women followed for 1 to 18 months (average, nine months) after delivery, and 27 of the 43 infants (63{\%}) born to those women became antigen-positive. Persistance of the antigen was more common than transient or intermittent antigenemia. Twelve had antigenemia when first tested, while 15 later developed antigenemia, usually during the first six months of life. Only one infant developed antibody to HG Ag (anti-HB Ag), and this occurred after transient antigenemia. The HB Ag was found in two of 32 (6{\%}) fathers, and in 18 of 27 (67{\%}) older siblings. The antigen was more common among siblings of antigen-positive than among those of antigen-negative infants. These findings demonstrate that in Taiwan, infants born to mothers who are asymptomatic carriers of HB Ag commonly become infected by heaptitis B (HB) virus. Exposure of infants near the time of birth may be important maintaining the high, chronic HB Ag carrier rate in Taiwan.",
author = "Karl Anderson and Stevens, {C. E.} and Tsuei, {J. J.} and Lee, {W. C.} and Sun, {S. C.} and P. Beasley",
year = "1975",
month = "12",
language = "English (US)",
volume = "129",
pages = "1389--1392",
journal = "JAMA Pediatrics",
issn = "2168-6203",
publisher = "American Medical Association",
number = "12",

}

TY - JOUR

T1 - Hepatitis B antigen in infants born to mothers with chronic hepatitis B antigenemia in Taiwan.

AU - Anderson, Karl

AU - Stevens, C. E.

AU - Tsuei, J. J.

AU - Lee, W. C.

AU - Sun, S. C.

AU - Beasley, P.

PY - 1975/12

Y1 - 1975/12

N2 - Hepatitis B antigen (HB Ag) was detected by complement fixation (CF) in serum samples of 7.5% of 1,106 pregnant Chinese women tested in Taipei, Taiwan. HG Ag persisted in all but one of 42 women followed for 1 to 18 months (average, nine months) after delivery, and 27 of the 43 infants (63%) born to those women became antigen-positive. Persistance of the antigen was more common than transient or intermittent antigenemia. Twelve had antigenemia when first tested, while 15 later developed antigenemia, usually during the first six months of life. Only one infant developed antibody to HG Ag (anti-HB Ag), and this occurred after transient antigenemia. The HB Ag was found in two of 32 (6%) fathers, and in 18 of 27 (67%) older siblings. The antigen was more common among siblings of antigen-positive than among those of antigen-negative infants. These findings demonstrate that in Taiwan, infants born to mothers who are asymptomatic carriers of HB Ag commonly become infected by heaptitis B (HB) virus. Exposure of infants near the time of birth may be important maintaining the high, chronic HB Ag carrier rate in Taiwan.

AB - Hepatitis B antigen (HB Ag) was detected by complement fixation (CF) in serum samples of 7.5% of 1,106 pregnant Chinese women tested in Taipei, Taiwan. HG Ag persisted in all but one of 42 women followed for 1 to 18 months (average, nine months) after delivery, and 27 of the 43 infants (63%) born to those women became antigen-positive. Persistance of the antigen was more common than transient or intermittent antigenemia. Twelve had antigenemia when first tested, while 15 later developed antigenemia, usually during the first six months of life. Only one infant developed antibody to HG Ag (anti-HB Ag), and this occurred after transient antigenemia. The HB Ag was found in two of 32 (6%) fathers, and in 18 of 27 (67%) older siblings. The antigen was more common among siblings of antigen-positive than among those of antigen-negative infants. These findings demonstrate that in Taiwan, infants born to mothers who are asymptomatic carriers of HB Ag commonly become infected by heaptitis B (HB) virus. Exposure of infants near the time of birth may be important maintaining the high, chronic HB Ag carrier rate in Taiwan.

UR - http://www.scopus.com/inward/record.url?scp=0016600011&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016600011&partnerID=8YFLogxK

M3 - Article

VL - 129

SP - 1389

EP - 1392

JO - JAMA Pediatrics

JF - JAMA Pediatrics

SN - 2168-6203

IS - 12

ER -