Hepatitis C remains leading indication for listings and receipt of liver transplantation for hepatocellular carcinoma

Ashwani K. Singal, Sanjaya K. Satapathy, Nancy Reau, Robert Wong, Yong Fang Kuo

Research output: Contribution to journalArticle

Abstract

Background and aims: With the availability of direct acting antivirals (DAA) for hepatitis C virus (HCV) infection, alcoholic liver disease (ALD) has evolved as the leading indication for listing and receipt of liver transplantation (LT) followed by non-alcoholic steatohepatitis and HCV infection. However, data are limited on etiology specific trends on listings and need for LT for hepatocellular carcinoma (HCC). Methods: We analyzed UNOS database to examine etiology specific listings and receipt of LT for patients with and without HCC. Listings and receipt of LT in the pre-DAA (2007–2012) era were compared to the DAA (2013–2018) era. Results: The analysis shows that among patients without HCV, there is a decreasing trend on the proportion of patients listed and transplanted for HCV, with simultaneous increase on listings and LT for NASH and ALD. Specifically for listings and transplants for HCC, the leading etiology remains HCV infection followed by NASH and ALD. The analysis also showed that LT for AH contributes to about 20% of increase in listings and receipt of LT for ALD.

Original languageEnglish (US)
JournalDigestive and Liver Disease
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Hepatitis C
Liver Transplantation
Hepatocellular Carcinoma
Alcoholic Liver Diseases
Hepacivirus
Virus Diseases
Antiviral Agents
Fatty Liver
Databases
Transplants

Keywords

  • HCC
  • HCV
  • OLT

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Hepatitis C remains leading indication for listings and receipt of liver transplantation for hepatocellular carcinoma. / Singal, Ashwani K.; Satapathy, Sanjaya K.; Reau, Nancy; Wong, Robert; Kuo, Yong Fang.

In: Digestive and Liver Disease, 01.01.2019.

Research output: Contribution to journalArticle

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abstract = "Background and aims: With the availability of direct acting antivirals (DAA) for hepatitis C virus (HCV) infection, alcoholic liver disease (ALD) has evolved as the leading indication for listing and receipt of liver transplantation (LT) followed by non-alcoholic steatohepatitis and HCV infection. However, data are limited on etiology specific trends on listings and need for LT for hepatocellular carcinoma (HCC). Methods: We analyzed UNOS database to examine etiology specific listings and receipt of LT for patients with and without HCC. Listings and receipt of LT in the pre-DAA (2007–2012) era were compared to the DAA (2013–2018) era. Results: The analysis shows that among patients without HCV, there is a decreasing trend on the proportion of patients listed and transplanted for HCV, with simultaneous increase on listings and LT for NASH and ALD. Specifically for listings and transplants for HCC, the leading etiology remains HCV infection followed by NASH and ALD. The analysis also showed that LT for AH contributes to about 20{\%} of increase in listings and receipt of LT for ALD.",
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AU - Kuo, Yong Fang

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