Hepatitis C status and infectious complications in the surgical intensive care unit

A retrospective analysis of 1,941 consecutive patients

Michael Kueht, Serge Bebko, Ryan Helmick, Samir Awad

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background Hepatitis C virus (HCV) infection is thought to be associated with immune dysfunction. We hypothesized that HCV status would be associated with increased infectious complications in the surgical intensive care unit (SICU). Methods All patients admitted to our SICU between 2008 and 2012 were included. We evaluated 90-day mortality and infectious complications in the SICU. Multivariate logistic regression was performed to identify predictors of infectious complications and 90-day mortality. Results A total of 1,941 patients were included. The HCV-positive group had a higher overall incidence of infectious complications (25% vs 18%), particularly ventilator-associated pneumonia (VAP) and bacteremia. The increased incidences of VAP and bacteremia persisted when cirrhotic patients were excluded. Prolonged intubation (Odds Ratio [OR] = 2.1), abdominal surgery (OR = 1.6), and model for end-stage liver disease ≥ 15 (OR = 1.4) were independent predictors of SICU infectious complications. Conclusions The HCV-positive group had an increased incidence of infectious complications in the SICU, particularly VAP and bacteremia. This effect persisted when cirrhotic patients were excluded.

Original languageEnglish (US)
Pages (from-to)1064-1070
Number of pages7
JournalAmerican Journal of Surgery
Volume211
Issue number6
DOIs
StatePublished - Jun 1 2016
Externally publishedYes

Fingerprint

Critical Care
Hepatitis C
Intensive Care Units
Ventilator-Associated Pneumonia
Hepacivirus
Bacteremia
Odds Ratio
Incidence
End Stage Liver Disease
Mortality
Virus Diseases
Intubation
Logistic Models

Keywords

  • Cirrhosis
  • Critical care
  • Hepatitis C
  • Nosocomial infection

ASJC Scopus subject areas

  • Surgery

Cite this

Hepatitis C status and infectious complications in the surgical intensive care unit : A retrospective analysis of 1,941 consecutive patients. / Kueht, Michael; Bebko, Serge; Helmick, Ryan; Awad, Samir.

In: American Journal of Surgery, Vol. 211, No. 6, 01.06.2016, p. 1064-1070.

Research output: Contribution to journalArticle

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