Hepatitis C virus infection in alcoholic hepatitis: Prevalence patterns and impact on in-hospital mortality

Ashwani K. Singal, Yong Fang Kuo, Bhupinderjit S. Anand

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

BACKGROUND: Hepatitis C virus (HCV) infection and alcohol abuse are common causes of cirrhosis in the USA. There are limited data on HCV prevalence and mortality trends in patients with alcoholic hepatitis (AH). AIM: The present study was carried out to assess HCV prevalence and mortality in AH patients. METHODS: Patients with a primary or a secondary discharge diagnosis of AH obtained from the Nationwide Inpatient Sample dataset (1998-2007) were stratified based on the presence of HCV. Factors associated with HCV positivity and in-hospital mortality were examined using multivariable logistic regression. RESULTS: Of 76 957 719 admissions, 111 726 had AH (7240 were HCV positive). The prevalence of HCV in AH patients was 3.6% in 1998 and 7.7% in 2007. In-hospital mortality was 3.2% (6.3% in 1998 and 2.7% in 2007), with an ∼7% annual decrease between 1998 and 2007. HCV was an independent predictor of in-hospital mortality after controlling for calendar year [odds ratio 1.29; 95% CI (1.12-1.49); P=0.0005]. CONCLUSION: Patients with AH have a higher prevalence of HCV compared with the general population. Although in-hospital mortality in AH patients has improved, HCV infection predicts a higher mortality. Further studies are required to determine the mechanisms of interaction of HCV and AH and develop treatment strategies to improve outcome of HCV-infected AH patients.

Original languageEnglish (US)
Pages (from-to)1178-1184
Number of pages7
JournalEuropean Journal of Gastroenterology and Hepatology
Volume24
Issue number10
DOIs
StatePublished - Oct 1 2012

Keywords

  • Nationwide Inpatient Sample
  • alcoholic hepatitis
  • hepatitis C virus

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Fingerprint Dive into the research topics of 'Hepatitis C virus infection in alcoholic hepatitis: Prevalence patterns and impact on in-hospital mortality'. Together they form a unique fingerprint.

  • Cite this