Heritability of nociception II. 'Types' of nociception revealed by genetic correlation analysis

Jeffrey S. Mogil, Sonya G. Wilson, Karine Bon, Seo Eun Lee, Kyungsoon Chung, Pnina Raber, Jeanne O. Pieper, Heather S. Hain, John K. Belknap, Lawrence Hubert, Greg I. Elmer, Jin Chung, Marshall Devor

Research output: Contribution to journalArticle

199 Citations (Scopus)

Abstract

Clinical pain syndromes, and experimental assays of nociception, are differentially affected by manipulations such as drug administration and exposure to environmental stress. This suggests that there are different 'types' of pain. We exploited genetic differences among inbred strains of mice in an attempt to define these primary 'types'; that is, to identify the fundamental parameters of pain processing. Eleven randomly-chosen inbred mouse strains were tested for their basal sensitivity on 12 common measures of nociception. These measures provided for a range of different nociceptive dimensions including noxious stimulus modality, location, duration and etiology, among others. Since individual members of inbred strains are identical at all genetic loci, the observation of correlated strain means in any given pair of nociceptive assays is an index of genetic correlation between these assays, and hence an indication of common physiological mediation. Obtained correlation matrices were subjected to multivariate analyses to identify constellations of nociceptive assays with common genetic mediation. This analysis revealed three major clusters of nociception: (1) baseline thermal nociception, (2) spontaneously-emitted responses to chemical stimuli, and (3) baseline mechanical sensitivity and cutaneous hypersensitivity. Many other nociceptive parameters that might a priori have been considered closely related proved to be genetically divergent. Copyright (C) 1999 International Association for the Study of Pain.

Original languageEnglish (US)
Pages (from-to)83-93
Number of pages11
JournalPain
Volume80
Issue number1-2
DOIs
StatePublished - Mar 1 1999

Fingerprint

Nociception
Inbred Strains Mice
Pain
Genetic Loci
Environmental Exposure
Hypersensitivity
Multivariate Analysis
Hot Temperature
Observation
Skin
Pharmaceutical Preparations

Keywords

  • Algesiometry
  • Inbred strains
  • Mouse genetics
  • Pain models
  • Strain differences

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Neurology
  • Neuroscience(all)
  • Pharmacology
  • Clinical Psychology

Cite this

Mogil, J. S., Wilson, S. G., Bon, K., Lee, S. E., Chung, K., Raber, P., ... Devor, M. (1999). Heritability of nociception II. 'Types' of nociception revealed by genetic correlation analysis. Pain, 80(1-2), 83-93. https://doi.org/10.1016/S0304-3959(98)00196-1

Heritability of nociception II. 'Types' of nociception revealed by genetic correlation analysis. / Mogil, Jeffrey S.; Wilson, Sonya G.; Bon, Karine; Lee, Seo Eun; Chung, Kyungsoon; Raber, Pnina; Pieper, Jeanne O.; Hain, Heather S.; Belknap, John K.; Hubert, Lawrence; Elmer, Greg I.; Chung, Jin; Devor, Marshall.

In: Pain, Vol. 80, No. 1-2, 01.03.1999, p. 83-93.

Research output: Contribution to journalArticle

Mogil, JS, Wilson, SG, Bon, K, Lee, SE, Chung, K, Raber, P, Pieper, JO, Hain, HS, Belknap, JK, Hubert, L, Elmer, GI, Chung, J & Devor, M 1999, 'Heritability of nociception II. 'Types' of nociception revealed by genetic correlation analysis', Pain, vol. 80, no. 1-2, pp. 83-93. https://doi.org/10.1016/S0304-3959(98)00196-1
Mogil, Jeffrey S. ; Wilson, Sonya G. ; Bon, Karine ; Lee, Seo Eun ; Chung, Kyungsoon ; Raber, Pnina ; Pieper, Jeanne O. ; Hain, Heather S. ; Belknap, John K. ; Hubert, Lawrence ; Elmer, Greg I. ; Chung, Jin ; Devor, Marshall. / Heritability of nociception II. 'Types' of nociception revealed by genetic correlation analysis. In: Pain. 1999 ; Vol. 80, No. 1-2. pp. 83-93.
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