HERPES-SIMPLEX VIRUS AS CAUSE OF BELL'S PALSY

David P. McCormick

doi:10.1016/S0140-6736(72)91499-7

HERPES-SIMPLEX VIRUS AS CAUSE OF BELL'S PALSY

David P. McCormick

Research output: Contribution to journal › Article › peer-review

234 Scopus citations

Abstract

A large percentage of cases of Bell's palsy may be caused by herpes-simplex virus (H.S.V.). It is suggested that H.S.V. takes up residence within the peripheral-nerve-cell axon, where it is protected from neutralising antibody and sensitised mononuclear immunocytes. Bell's palsy may result when H.S.V. ruptures from the nerve axon, infects the Schwann sheath, and progresses centripetally. When the swelling caused by the herpetic endoneuritis reaches the enclosed space of the bony fallopian canal, compression of the facial nerve results in paralysis.

Original language	English (US)
Pages (from-to)	937-939
Number of pages	3
Journal	The Lancet
Volume	299
Issue number	7757
DOIs	https://doi.org/10.1016/S0140-6736(72)91499-7
State	Published - Apr 29 1972
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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title = "HERPES-SIMPLEX VIRUS AS CAUSE OF BELL'S PALSY",

abstract = "A large percentage of cases of Bell's palsy may be caused by herpes-simplex virus (H.S.V.). It is suggested that H.S.V. takes up residence within the peripheral-nerve-cell axon, where it is protected from neutralising antibody and sensitised mononuclear immunocytes. Bell's palsy may result when H.S.V. ruptures from the nerve axon, infects the Schwann sheath, and progresses centripetally. When the swelling caused by the herpetic endoneuritis reaches the enclosed space of the bony fallopian canal, compression of the facial nerve results in paralysis.",

author = "McCormick, {David P.}",

note = "Funding Information: F.l.M.L.T., for technical assistance; to the paediatricians of the Children{\textquoteright}s Hospital who allowed us to study patients under their care; and to the nursing staff for their helpful cooperation. One of us (J. R. M.) was in receipt of a research grant from the United Birmingham Hospitals endowment research fund.",

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doi = "10.1016/S0140-6736(72)91499-7",

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N2 - A large percentage of cases of Bell's palsy may be caused by herpes-simplex virus (H.S.V.). It is suggested that H.S.V. takes up residence within the peripheral-nerve-cell axon, where it is protected from neutralising antibody and sensitised mononuclear immunocytes. Bell's palsy may result when H.S.V. ruptures from the nerve axon, infects the Schwann sheath, and progresses centripetally. When the swelling caused by the herpetic endoneuritis reaches the enclosed space of the bony fallopian canal, compression of the facial nerve results in paralysis.

AB - A large percentage of cases of Bell's palsy may be caused by herpes-simplex virus (H.S.V.). It is suggested that H.S.V. takes up residence within the peripheral-nerve-cell axon, where it is protected from neutralising antibody and sensitised mononuclear immunocytes. Bell's palsy may result when H.S.V. ruptures from the nerve axon, infects the Schwann sheath, and progresses centripetally. When the swelling caused by the herpetic endoneuritis reaches the enclosed space of the bony fallopian canal, compression of the facial nerve results in paralysis.

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HERPES-SIMPLEX VIRUS AS CAUSE OF BELL'S PALSY

Abstract

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