Herpes virus inactivation by chemical carcinogens: Differential inactivation of herpes simplex viruses by 4‐nitroquinoline 1‐oxide and related compounds

Dan Speelman; Jui‐Lien H. Li; V. ‐M Sadagopa Ramanujam; Marvin S. Legator; Thomas Albrecht

doi:10.1002/em.2860030407

Herpes virus inactivation by chemical carcinogens: Differential inactivation of herpes simplex viruses by 4‐nitroquinoline 1‐oxide and related compounds

Dan Speelman, Jui‐Lien H. Li, V. ‐M Sadagopa Ramanujam, Marvin S. Legator, Thomas Albrecht

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Abstract

Treatment of stocks of herpes simplex virus type 1 (HSV‐1) and type 2 (HSV‐2) with the chemical carcinogen 4‐nitroquinoline 1‐oxide (NQO) resulted in inactivation of virus infectivity at rates which were directly dependent on the concentration of NQO and interval of exposure to NQO. HSV‐1 strains were more sensitive than HSV‐2 strains to inactivation by NQO, although survival curves of both HSV types were multicomponent. Exposure of HSV‐2 to a related group of chemicals suggested that the structural specificity required for inactivation of this virus was similar to that established by previous in vivo carcinogenicity tests.

Original language	English (US)
Pages (from-to)	467-476
Number of pages	10
Journal	Environmental Mutagenesis
Volume	3
Issue number	4
DOIs	https://doi.org/10.1002/em.2860030407
State	Published - 1981

Keywords

4‐nitroquinoline 1‐oxide
cocarcinogenesis
herpes simplex virus
mutagenesis

ASJC Scopus subject areas

Genetics
Health, Toxicology and Mutagenesis

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title = "Herpes virus inactivation by chemical carcinogens: Differential inactivation of herpes simplex viruses by 4‐nitroquinoline 1‐oxide and related compounds",

abstract = "Treatment of stocks of herpes simplex virus type 1 (HSV‐1) and type 2 (HSV‐2) with the chemical carcinogen 4‐nitroquinoline 1‐oxide (NQO) resulted in inactivation of virus infectivity at rates which were directly dependent on the concentration of NQO and interval of exposure to NQO. HSV‐1 strains were more sensitive than HSV‐2 strains to inactivation by NQO, although survival curves of both HSV types were multicomponent. Exposure of HSV‐2 to a related group of chemicals suggested that the structural specificity required for inactivation of this virus was similar to that established by previous in vivo carcinogenicity tests.",

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T2 - Differential inactivation of herpes simplex viruses by 4‐nitroquinoline 1‐oxide and related compounds

AU - Speelman, Dan

AU - Li, Jui‐Lien H.

AU - Ramanujam, V. ‐M Sadagopa

AU - Legator, Marvin S.

AU - Albrecht, Thomas

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AB - Treatment of stocks of herpes simplex virus type 1 (HSV‐1) and type 2 (HSV‐2) with the chemical carcinogen 4‐nitroquinoline 1‐oxide (NQO) resulted in inactivation of virus infectivity at rates which were directly dependent on the concentration of NQO and interval of exposure to NQO. HSV‐1 strains were more sensitive than HSV‐2 strains to inactivation by NQO, although survival curves of both HSV types were multicomponent. Exposure of HSV‐2 to a related group of chemicals suggested that the structural specificity required for inactivation of this virus was similar to that established by previous in vivo carcinogenicity tests.

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Herpes virus inactivation by chemical carcinogens: Differential inactivation of herpes simplex viruses by 4‐nitroquinoline 1‐oxide and related compounds

Abstract

Keywords

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