Herpes virus inactivation by chemical carcinogens: Differential inactivation of herpes simplex viruses by 4‐nitroquinoline 1‐oxide and related compounds

Dan Speelman, Jui‐Lien H. Li, V. ‐M Sadagopa Ramanujam, Marvin S. Legator, Thomas Albrecht

    Research output: Contribution to journalArticlepeer-review

    3 Scopus citations

    Abstract

    Treatment of stocks of herpes simplex virus type 1 (HSV‐1) and type 2 (HSV‐2) with the chemical carcinogen 4‐nitroquinoline 1‐oxide (NQO) resulted in inactivation of virus infectivity at rates which were directly dependent on the concentration of NQO and interval of exposure to NQO. HSV‐1 strains were more sensitive than HSV‐2 strains to inactivation by NQO, although survival curves of both HSV types were multicomponent. Exposure of HSV‐2 to a related group of chemicals suggested that the structural specificity required for inactivation of this virus was similar to that established by previous in vivo carcinogenicity tests.

    Original languageEnglish (US)
    Pages (from-to)467-476
    Number of pages10
    JournalEnvironmental Mutagenesis
    Volume3
    Issue number4
    DOIs
    StatePublished - 1981

    Keywords

    • 4‐nitroquinoline 1‐oxide
    • cocarcinogenesis
    • herpes simplex virus
    • mutagenesis

    ASJC Scopus subject areas

    • Genetics
    • Health, Toxicology and Mutagenesis

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