Herpes virus inactivation by chemical carcinogens: Differential inactivation of herpes simplex viruses by 4‐nitroquinoline 1‐oxide and related compounds

Dan Speelman, Jui‐Lien H. Li, V. ‐M Sadagopa Ramanujam, Marvin S. Legator, Thomas Albrecht

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Treatment of stocks of herpes simplex virus type 1 (HSV‐1) and type 2 (HSV‐2) with the chemical carcinogen 4‐nitroquinoline 1‐oxide (NQO) resulted in inactivation of virus infectivity at rates which were directly dependent on the concentration of NQO and interval of exposure to NQO. HSV‐1 strains were more sensitive than HSV‐2 strains to inactivation by NQO, although survival curves of both HSV types were multicomponent. Exposure of HSV‐2 to a related group of chemicals suggested that the structural specificity required for inactivation of this virus was similar to that established by previous in vivo carcinogenicity tests.

Original languageEnglish (US)
Pages (from-to)467-476
Number of pages10
JournalEnvironmental Mutagenesis
Volume3
Issue number4
DOIs
StatePublished - 1981

Keywords

  • 4‐nitroquinoline 1‐oxide
  • cocarcinogenesis
  • herpes simplex virus
  • mutagenesis

ASJC Scopus subject areas

  • Genetics
  • Health, Toxicology and Mutagenesis

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