Heterogeneity of asthma in society

Rohit Divekar, William J. Calhoun

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

There has been an increased interest in studying other factors that affect asthma pathogenesis and cause heterogeneity in prevalence and incidence of asthma. The reason there are such varied expression patterns of disease in asthmatics is because of multiple variables that affect the pathogenesis of asthma. As an exemplar of an epidemiologic variable, we will discuss geographical location, obesity and vitamin D status of the individual, and their effects on asthma burden in humans. There is varying data regarding the prevalence or severity of asthma in urban versus rural setting which is likely related to the difference of the populations studied, complexity of causal variables involved, and local geographic factors. In addition to cross-sectional and cohort studies in humans, animal models and studies have established a link between asthma and obesity by investigating the mechanisms affecting both disease processes. The complicated interrelationship between obesity and asthma is an active area of epidemiological and experimental research with new insights being discovered at a rapid pace. Finally, vitamin D, an important immunomodulator thought to be important in pathogenesis of asthma, has both mechanistic and therapeutic implications in treatment of asthma. The influences of these factors on the clinical expression of asthma are discussed below.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
Pages31-41
Number of pages11
Volume795
DOIs
StatePublished - 2014

Publication series

NameAdvances in Experimental Medicine and Biology
Volume795
ISSN (Print)00652598

Fingerprint

Vitamin D
Asthma
Immunologic Factors
Animals
Obesity
Geography
Cohort Studies
Animal Models
Cross-Sectional Studies
Incidence
Research

Keywords

  • Heterogeneous expression of asthma in population
  • Obesity
  • Population differences in asthma burden
  • Public health and asthma
  • Rural
  • Urbanization
  • Vitamin D

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Divekar, R., & Calhoun, W. J. (2014). Heterogeneity of asthma in society. In Advances in Experimental Medicine and Biology (Vol. 795, pp. 31-41). (Advances in Experimental Medicine and Biology; Vol. 795). https://doi.org/10.1007/978-1-4614-8603-9-3

Heterogeneity of asthma in society. / Divekar, Rohit; Calhoun, William J.

Advances in Experimental Medicine and Biology. Vol. 795 2014. p. 31-41 (Advances in Experimental Medicine and Biology; Vol. 795).

Research output: Chapter in Book/Report/Conference proceedingChapter

Divekar, R & Calhoun, WJ 2014, Heterogeneity of asthma in society. in Advances in Experimental Medicine and Biology. vol. 795, Advances in Experimental Medicine and Biology, vol. 795, pp. 31-41. https://doi.org/10.1007/978-1-4614-8603-9-3
Divekar R, Calhoun WJ. Heterogeneity of asthma in society. In Advances in Experimental Medicine and Biology. Vol. 795. 2014. p. 31-41. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-1-4614-8603-9-3
Divekar, Rohit ; Calhoun, William J. / Heterogeneity of asthma in society. Advances in Experimental Medicine and Biology. Vol. 795 2014. pp. 31-41 (Advances in Experimental Medicine and Biology).
@inbook{478ed4544da04b69956c314cac4b1fac,
title = "Heterogeneity of asthma in society",
abstract = "There has been an increased interest in studying other factors that affect asthma pathogenesis and cause heterogeneity in prevalence and incidence of asthma. The reason there are such varied expression patterns of disease in asthmatics is because of multiple variables that affect the pathogenesis of asthma. As an exemplar of an epidemiologic variable, we will discuss geographical location, obesity and vitamin D status of the individual, and their effects on asthma burden in humans. There is varying data regarding the prevalence or severity of asthma in urban versus rural setting which is likely related to the difference of the populations studied, complexity of causal variables involved, and local geographic factors. In addition to cross-sectional and cohort studies in humans, animal models and studies have established a link between asthma and obesity by investigating the mechanisms affecting both disease processes. The complicated interrelationship between obesity and asthma is an active area of epidemiological and experimental research with new insights being discovered at a rapid pace. Finally, vitamin D, an important immunomodulator thought to be important in pathogenesis of asthma, has both mechanistic and therapeutic implications in treatment of asthma. The influences of these factors on the clinical expression of asthma are discussed below.",
keywords = "Heterogeneous expression of asthma in population, Obesity, Population differences in asthma burden, Public health and asthma, Rural, Urbanization, Vitamin D",
author = "Rohit Divekar and Calhoun, {William J.}",
year = "2014",
doi = "10.1007/978-1-4614-8603-9-3",
language = "English (US)",
isbn = "9781461486022",
volume = "795",
series = "Advances in Experimental Medicine and Biology",
pages = "31--41",
booktitle = "Advances in Experimental Medicine and Biology",

}

TY - CHAP

T1 - Heterogeneity of asthma in society

AU - Divekar, Rohit

AU - Calhoun, William J.

PY - 2014

Y1 - 2014

N2 - There has been an increased interest in studying other factors that affect asthma pathogenesis and cause heterogeneity in prevalence and incidence of asthma. The reason there are such varied expression patterns of disease in asthmatics is because of multiple variables that affect the pathogenesis of asthma. As an exemplar of an epidemiologic variable, we will discuss geographical location, obesity and vitamin D status of the individual, and their effects on asthma burden in humans. There is varying data regarding the prevalence or severity of asthma in urban versus rural setting which is likely related to the difference of the populations studied, complexity of causal variables involved, and local geographic factors. In addition to cross-sectional and cohort studies in humans, animal models and studies have established a link between asthma and obesity by investigating the mechanisms affecting both disease processes. The complicated interrelationship between obesity and asthma is an active area of epidemiological and experimental research with new insights being discovered at a rapid pace. Finally, vitamin D, an important immunomodulator thought to be important in pathogenesis of asthma, has both mechanistic and therapeutic implications in treatment of asthma. The influences of these factors on the clinical expression of asthma are discussed below.

AB - There has been an increased interest in studying other factors that affect asthma pathogenesis and cause heterogeneity in prevalence and incidence of asthma. The reason there are such varied expression patterns of disease in asthmatics is because of multiple variables that affect the pathogenesis of asthma. As an exemplar of an epidemiologic variable, we will discuss geographical location, obesity and vitamin D status of the individual, and their effects on asthma burden in humans. There is varying data regarding the prevalence or severity of asthma in urban versus rural setting which is likely related to the difference of the populations studied, complexity of causal variables involved, and local geographic factors. In addition to cross-sectional and cohort studies in humans, animal models and studies have established a link between asthma and obesity by investigating the mechanisms affecting both disease processes. The complicated interrelationship between obesity and asthma is an active area of epidemiological and experimental research with new insights being discovered at a rapid pace. Finally, vitamin D, an important immunomodulator thought to be important in pathogenesis of asthma, has both mechanistic and therapeutic implications in treatment of asthma. The influences of these factors on the clinical expression of asthma are discussed below.

KW - Heterogeneous expression of asthma in population

KW - Obesity

KW - Population differences in asthma burden

KW - Public health and asthma

KW - Rural

KW - Urbanization

KW - Vitamin D

UR - http://www.scopus.com/inward/record.url?scp=84892993681&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84892993681&partnerID=8YFLogxK

U2 - 10.1007/978-1-4614-8603-9-3

DO - 10.1007/978-1-4614-8603-9-3

M3 - Chapter

SN - 9781461486022

VL - 795

T3 - Advances in Experimental Medicine and Biology

SP - 31

EP - 41

BT - Advances in Experimental Medicine and Biology

ER -