Heterogeneity of estrogen binding sites in mammary tumors

J. H. Clark, C. S. Watson, B. M. Markaverich, J. S. Syne, W. B. Panko

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


This paper provides a brief summary of our recent work on the heterogeneity of estradiol binding sites in mammary tumors of the mouse and human. Mammary tumors from both species contain the classical estrogen receptor and a second site(s) which we call type II. These type II sites are found in the cytoplasmic and nuclear compartments of both tumors, and can interfere with the measurement of estrogen receptors. The function of type II sites is not known; however, an assessment of these sites in conjunction with an accurate measurement of the estrogen receptor may provide a clearer picture of the true hormone dependence of breast tumors.

Original languageEnglish (US)
Pages (from-to)61-65
Number of pages5
JournalBreast Cancer Research and Treatment
Issue number1
StatePublished - Mar 1983
Externally publishedYes


  • estrogen receptor
  • human mammary tumors
  • mouse mammary tumors
  • type II estrogen binding sites

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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