Heterogeneity of response to therapy

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

As noted in prior chapters, US national and international guidelines provide a consistent approach to initial management of asthma, based on easily observed physical and physiologic findings, and a detailed history. From those data, a rational initial therapeutic regimen can be prescribed. In many cases, such therapy results in near complete control of asthma symptoms, restoration of normal lung physiology, and elimination of exacerbations. In fact, such improvement is frequent enough that therapeutic responsiveness to asthma treatments was thought to be nearly universal. However, it is not uncommon for patients to return with incomplete, or even trivial improvement in these clinical metrics of control (Langmack and Martin Curr Opin Pulm Med 16:13-18, 2010). In this chapter, we review the current literature on the variability of response to commonly used therapeutic agents in asthma.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages117-122
Number of pages6
Volume795
ISBN (Print)9781461486022
DOIs
StatePublished - 2014

Publication series

NameAdvances in Experimental Medicine and Biology
Volume795
ISSN (Print)00652598

Keywords

  • Asthma
  • Heterogeneity
  • IL-13
  • Inhaled steroid
  • Molecular phenotype
  • Montelukast
  • Periostin
  • Predictive phenotype
  • Therapeutic response

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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  • Cite this

    Calhoun, W. (2014). Heterogeneity of response to therapy. In Advances in Experimental Medicine and Biology (Vol. 795, pp. 117-122). (Advances in Experimental Medicine and Biology; Vol. 795). Springer New York LLC. https://doi.org/10.1007/978-1-4614-8603-9_8