High dose methotrexate therapy of solid tumors: observations relating to clinical toxicity

William H. Isacoff; Courtney M. Townsend; Frederick R. Eilber; Terry Forster; Donald L. Morton; Jerome B. Block

doi:10.1002/mpo.2950020313

High dose methotrexate therapy of solid tumors: observations relating to clinical toxicity

William H. Isacoff, Courtney M. Townsend, Frederick R. Eilber, Terry Forster, Donald L. Morton, Jerome B. Block

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

In clinical studies performed during 111 infusions of high dose methotrexate (MTX) we have evolved a clinical and laboratory protocol which permits such therapy without prohibitive risk to the patient. The plasma MTX data obtained indicate that pharmacokinetic disposition is dose related during these infusions and that such data are useful in identifying patients at risk from serious toxicity.

Original language	English (US)
Pages (from-to)	319-325
Number of pages	7
Journal	Medical and Pediatric Oncology
Volume	2
Issue number	3
DOIs	https://doi.org/10.1002/mpo.2950020313
State	Published - 1976
Externally published	Yes

Keywords

high dose methotrexate
pharmacology
toxicity

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Oncology
Cancer Research

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10.1002/mpo.2950020313

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abstract = "In clinical studies performed during 111 infusions of high dose methotrexate (MTX) we have evolved a clinical and laboratory protocol which permits such therapy without prohibitive risk to the patient. The plasma MTX data obtained indicate that pharmacokinetic disposition is dose related during these infusions and that such data are useful in identifying patients at risk from serious toxicity.",

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T2 - observations relating to clinical toxicity

AU - Isacoff, William H.

AU - Townsend, Courtney M.

AU - Eilber, Frederick R.

AU - Forster, Terry

AU - Morton, Donald L.

AU - Block, Jerome B.

PY - 1976

Y1 - 1976

N2 - In clinical studies performed during 111 infusions of high dose methotrexate (MTX) we have evolved a clinical and laboratory protocol which permits such therapy without prohibitive risk to the patient. The plasma MTX data obtained indicate that pharmacokinetic disposition is dose related during these infusions and that such data are useful in identifying patients at risk from serious toxicity.

AB - In clinical studies performed during 111 infusions of high dose methotrexate (MTX) we have evolved a clinical and laboratory protocol which permits such therapy without prohibitive risk to the patient. The plasma MTX data obtained indicate that pharmacokinetic disposition is dose related during these infusions and that such data are useful in identifying patients at risk from serious toxicity.

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KW - pharmacology

KW - toxicity

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ER -

High dose methotrexate therapy of solid tumors: observations relating to clinical toxicity

Abstract

Keywords

ASJC Scopus subject areas

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