High dose methotrexate therapy of solid tumors: observations relating to clinical toxicity

William H. Isacoff, Courtney M. Townsend, Frederick R. Eilber, Terry Forster, Donald L. Morton, Jerome B. Block

Research output: Contribution to journalArticle

42 Scopus citations


In clinical studies performed during 111 infusions of high dose methotrexate (MTX) we have evolved a clinical and laboratory protocol which permits such therapy without prohibitive risk to the patient. The plasma MTX data obtained indicate that pharmacokinetic disposition is dose related during these infusions and that such data are useful in identifying patients at risk from serious toxicity.

Original languageEnglish (US)
Pages (from-to)319-325
Number of pages7
JournalMedical and Pediatric Oncology
Issue number3
StatePublished - 1976
Externally publishedYes



  • high dose methotrexate
  • pharmacology
  • toxicity

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Cancer Research

Cite this