High dose methotrexate therapy of solid tumors: observations relating to clinical toxicity

William H. Isacoff, Courtney M. Townsend, Frederick R. Eilber, Terry Forster, Donald L. Morton, Jerome B. Block

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

In clinical studies performed during 111 infusions of high dose methotrexate (MTX) we have evolved a clinical and laboratory protocol which permits such therapy without prohibitive risk to the patient. The plasma MTX data obtained indicate that pharmacokinetic disposition is dose related during these infusions and that such data are useful in identifying patients at risk from serious toxicity.

Original languageEnglish (US)
Pages (from-to)319-325
Number of pages7
JournalMedical and Pediatric Oncology
Volume2
Issue number3
DOIs
StatePublished - 1976
Externally publishedYes

    Fingerprint

Keywords

  • high dose methotrexate
  • pharmacology
  • toxicity

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Cancer Research

Cite this