High-LET radiation carcinogenesis

R. J M Fry, R. L. Ullrich, P. Powers-Risius, E. L. Alpen, E. J. Ainsworth

Research output: Contribution to journalArticle

31 Scopus citations


Recent results for neutron radiation-induced tumors are presented to illustrate the complexities of the dose-response curves for high-LET radiation. It is suggested that in order to derive an appropriate model for dose-response curves for the induction of tumors by high-LET radiation it is necessary to take into account dose distribution, cell killing and the susceptibility of the tissue under study. Preliminary results for the induction of Harderian gland tumors in mice exposed to various heavy ion beams are presented. The results suggest that the effectiveness of the heavy ion beams increases with increasing LET. The slopes of the dose-response curves for the different high-LET radiations decrease between 20 and 40 rads and therefore comparisons of the relative effectiveness should be made from data obtained at doses below about 20-30 rads.

Original languageEnglish (US)
Pages (from-to)241-248
Number of pages8
JournalAdvances in Space Research
Issue number8
StatePublished - 1983
Externally publishedYes


ASJC Scopus subject areas

  • Space and Planetary Science
  • Astronomy and Astrophysics

Cite this

Fry, R. J. M., Ullrich, R. L., Powers-Risius, P., Alpen, E. L., & Ainsworth, E. J. (1983). High-LET radiation carcinogenesis. Advances in Space Research, 3(8), 241-248. https://doi.org/10.1016/0273-1177(83)90194-1