TY - JOUR
T1 - High-mobility group box 1 at the time of parturition in women with gestational diabetes mellitus
AU - Hill, Ashley V.
AU - Menon, Ramkumar
AU - Perez-Patron, Maria
AU - Carrillo, Genny
AU - Xu, Xiaohui
AU - Taylor, Brandie D.
N1 - Funding Information:
Funding information This research was supported by a grant from the Discovery Foundation to BDT, and supported by a National Institute of Child Health & Human Development 5T32HD087162-03 for AVH. Subject data and specimens were obtained following full and informed subject consent with the generous support from the Departments of Obstetrics and Gynecology and Pathology and Laboratory Medicine at Texas Children's Hospital and Baylor College of Medicine on the PeriBank protocol (IRB H-26364, Dr Kjersti Aagaard PI). Briefly, PeriBank is a biobank focusing on specimens collected during the perinatal period, which encompasses state-of-the-science processing and storage of specimens according to Best Practices recommended by International Society for Biological and Environmental Repositories (ISBER). Recruitment, specimen processing, storage, and retrieval systems were developed by a multidisciplinary consortium of obstetrician-gynecologists and maternal-fetal medicine specialists, pathologists, nurses, and laboratory staff.
Publisher Copyright:
© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
PY - 2019/11/1
Y1 - 2019/11/1
N2 - Problem: High-mobility group box 1 (HMGB1), a danger-associated molecular pattern marker, may indicate sterile inflammation through innate immune pathways. HMGB1 is implicated in hyperglycemia and excess glucose in trophoblast. Metabolic dysfunction and dyslipidemia are associated with gestational diabetes mellitus (GDM), but few studies examined associations between HMGB1 and GDM. We determined HMGB1 levels, and the ratio of HMGB1 to innate immune markers, in women with GDM at parturition. Method of study: This case-control study of 50 GDM pregnancies and 100 healthy controls utilized data and plasma samples from PeriBank. HMGB1, pentraxin-3, and interleukin (IL)-6 were measured by ELISA. Logistic regression calculated odds ratios (OR) and 95% confidence intervals (CI) adjusting for age, pre-pregnancy body mass index, and type of labor. Results: There were no significant associations between HMGB1 and GDM. The ratio of HMGB1 to pentraxin-3 and IL-6 did not alter the odds of GDM. There was a significant statistical interaction between HMGB1 and maternal age (P =.02). When associations were examined by age groups, HMGB1 was associated with reduced odds of HMGB1 among women ≤25 (AOR = 0.007 CI 95% '0.001-0.3). Odds ratios increased as age increased (AOR range 1.2-3.8) but results were not statistically significant. Conclusion: High-mobility group box 1 was not associated with GDM. However, we found evidence that maternal age was a potential effect modifier of the relationship between HMGB1 and GDM. As there is growing evidence that HMGB1 may play important roles in reproduction, future studies should explore maternal factors that may alter HMGB1 levels.
AB - Problem: High-mobility group box 1 (HMGB1), a danger-associated molecular pattern marker, may indicate sterile inflammation through innate immune pathways. HMGB1 is implicated in hyperglycemia and excess glucose in trophoblast. Metabolic dysfunction and dyslipidemia are associated with gestational diabetes mellitus (GDM), but few studies examined associations between HMGB1 and GDM. We determined HMGB1 levels, and the ratio of HMGB1 to innate immune markers, in women with GDM at parturition. Method of study: This case-control study of 50 GDM pregnancies and 100 healthy controls utilized data and plasma samples from PeriBank. HMGB1, pentraxin-3, and interleukin (IL)-6 were measured by ELISA. Logistic regression calculated odds ratios (OR) and 95% confidence intervals (CI) adjusting for age, pre-pregnancy body mass index, and type of labor. Results: There were no significant associations between HMGB1 and GDM. The ratio of HMGB1 to pentraxin-3 and IL-6 did not alter the odds of GDM. There was a significant statistical interaction between HMGB1 and maternal age (P =.02). When associations were examined by age groups, HMGB1 was associated with reduced odds of HMGB1 among women ≤25 (AOR = 0.007 CI 95% '0.001-0.3). Odds ratios increased as age increased (AOR range 1.2-3.8) but results were not statistically significant. Conclusion: High-mobility group box 1 was not associated with GDM. However, we found evidence that maternal age was a potential effect modifier of the relationship between HMGB1 and GDM. As there is growing evidence that HMGB1 may play important roles in reproduction, future studies should explore maternal factors that may alter HMGB1 levels.
KW - gestational diabetes mellitus
KW - high-mobility group box 1
KW - innate immunity
KW - pregnancy
UR - http://www.scopus.com/inward/record.url?scp=85070777602&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85070777602&partnerID=8YFLogxK
U2 - 10.1111/aji.13175
DO - 10.1111/aji.13175
M3 - Article
C2 - 31353785
AN - SCOPUS:85070777602
SN - 1046-7408
VL - 82
JO - American Journal of Reproductive Immunology
JF - American Journal of Reproductive Immunology
IS - 5
M1 - e13175
ER -