High-performance liquid chromatography of arginine-containing neuropeptides by precolumn derivatization and fluorimetric detection

Danxia Liu, David J. Mc Adoo

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

A previously developed fluorescence method for determining leupeptin and the angiotensins is shown to be applicable to assaying other small arginine-containing peptides. In this procedure arginine residues are derivatized by reaction with benzoin. Femtomole sensivity is obtainable with this method. However, it cannot be used with larger arginine-containing peptides because those fragment upon derivatization.

Original languageEnglish (US)
Pages (from-to)2049-2057
Number of pages9
JournalJournal of Liquid Chromatography
Volume13
Issue number10
DOIs
StatePublished - Jun 1 1990

ASJC Scopus subject areas

  • Molecular Medicine

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