High Potency of a Bivalent Human VH Domain in SARS-CoV-2 Animal Models

Wei Li, Alexandra Schäfer, Swarali S. Kulkarni, Xianglei Liu, David R. Martinez, Chuan Chen, Zehua Sun, Sarah R. Leist, Aleksandra Drelich, Liyong Zhang, Marcin L. Ura, Alison Berezuk, Sagar Chittori, Karoline Leopold, Dhiraj Mannar, Shanti S. Srivastava, Xing Zhu, Eric C. Peterson, Chien Te Tseng, John W. MellorsDarryl Falzarano, Sriram Subramaniam, Ralph S. Baric, Dimiter S. Dimitrov

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

A high-affinity human antibody domain, VH ab8, specific for SARS-CoV-2, bound to all three S protomers competing with ACE2. The relatively small size and bivalency of VH-Fc ab8 contributed to its high potency in two animal models of infection.

Original languageEnglish (US)
Pages (from-to)429-441.e16
JournalCell
Volume183
Issue number2
DOIs
StatePublished - Oct 15 2020

Keywords

  • SARS-CoV-2
  • electron microscopy
  • human V antibody domain
  • mouse and hamster models
  • virus neutralization

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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