High-resolution ultrasound imaging and noninvasive optoacoustic monitoring of blood variables in peripheral blood vessels

Irene Y. Petrov, Yuriy Petrov, Donald Prough, Rinat Esenaliev

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

Ultrasound imaging is being widely used in clinics to obtain diagnostic information non-invasively and in real time. A high-resolution ultrasound imaging platform, Vevo (VisualSonics, Inc.) provides in vivo, real-time images with exceptional resolution (up to 30 microns) using high-frequency transducers (up to 80 MHz). Recently, we built optoacoustic systems for probing radial artery and peripheral veins that can be used for noninvasive monitoring of total hemoglobin concentration, oxyhemoglobin saturation, and concentration of important endogenous and exogenous chromophores (such as ICG). In this work we used the high-resolution ultrasound imaging system Vevo 770 for visualization of the radial artery and peripheral veins and acquired corresponding optoacoustic signals from them using the optoacoustic systems. Analysis of the optoacoustic data with a specially developed algorithm allowed for measurement of blood oxygenation in the blood vessels as well as for continuous, real-time monitoring of arterial and venous blood oxygenation. Our results indicate that: 1) the optoacoustic technique (unlike pure optical approaches and other noninvasive techniques) is capable of accurate peripheral venous oxygenation measurement; and 2) peripheral venous oxygenation is dependent on skin temperature and local hemodynamics. Moreover, we performed for the first time (to the best of our knowledge) a comparative study of optoacoustic arterial oximetry and a standard pulse oximeter in humans and demonstrated superior performance of the optoacoustic arterial oximeter, in particular at low blood flow.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7899
DOIs
StatePublished - 2011
EventPhotons Plus Ultrasound: Imaging and Sensing 2011 - San Francisco, CA, United States
Duration: Jan 23 2011Jan 25 2011

Other

OtherPhotons Plus Ultrasound: Imaging and Sensing 2011
CountryUnited States
CitySan Francisco, CA
Period1/23/111/25/11

Fingerprint

Photoacoustic effect
oxygenation
blood vessels
Blood vessels
blood
Blood Vessels
Ultrasonography
Radial Artery
Blood
Ultrasonics
Oxygenation
Imaging techniques
Monitoring
Photoacoustic Techniques
Veins
high resolution
arteries
veins
Oximeters
Oxyhemoglobins

Keywords

  • Blood variables
  • High resolution
  • Noninvasive monitoring
  • Optoacoustics
  • Oxygenation
  • Ultrasound imaging

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Petrov, I. Y., Petrov, Y., Prough, D., & Esenaliev, R. (2011). High-resolution ultrasound imaging and noninvasive optoacoustic monitoring of blood variables in peripheral blood vessels. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 7899). [78990B] https://doi.org/10.1117/12.879470

High-resolution ultrasound imaging and noninvasive optoacoustic monitoring of blood variables in peripheral blood vessels. / Petrov, Irene Y.; Petrov, Yuriy; Prough, Donald; Esenaliev, Rinat.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7899 2011. 78990B.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Petrov, IY, Petrov, Y, Prough, D & Esenaliev, R 2011, High-resolution ultrasound imaging and noninvasive optoacoustic monitoring of blood variables in peripheral blood vessels. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 7899, 78990B, Photons Plus Ultrasound: Imaging and Sensing 2011, San Francisco, CA, United States, 1/23/11. https://doi.org/10.1117/12.879470
Petrov, Irene Y. ; Petrov, Yuriy ; Prough, Donald ; Esenaliev, Rinat. / High-resolution ultrasound imaging and noninvasive optoacoustic monitoring of blood variables in peripheral blood vessels. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7899 2011.
@inproceedings{300c8f43289d4e5fa0ae2a1c10cbeade,
title = "High-resolution ultrasound imaging and noninvasive optoacoustic monitoring of blood variables in peripheral blood vessels",
abstract = "Ultrasound imaging is being widely used in clinics to obtain diagnostic information non-invasively and in real time. A high-resolution ultrasound imaging platform, Vevo (VisualSonics, Inc.) provides in vivo, real-time images with exceptional resolution (up to 30 microns) using high-frequency transducers (up to 80 MHz). Recently, we built optoacoustic systems for probing radial artery and peripheral veins that can be used for noninvasive monitoring of total hemoglobin concentration, oxyhemoglobin saturation, and concentration of important endogenous and exogenous chromophores (such as ICG). In this work we used the high-resolution ultrasound imaging system Vevo 770 for visualization of the radial artery and peripheral veins and acquired corresponding optoacoustic signals from them using the optoacoustic systems. Analysis of the optoacoustic data with a specially developed algorithm allowed for measurement of blood oxygenation in the blood vessels as well as for continuous, real-time monitoring of arterial and venous blood oxygenation. Our results indicate that: 1) the optoacoustic technique (unlike pure optical approaches and other noninvasive techniques) is capable of accurate peripheral venous oxygenation measurement; and 2) peripheral venous oxygenation is dependent on skin temperature and local hemodynamics. Moreover, we performed for the first time (to the best of our knowledge) a comparative study of optoacoustic arterial oximetry and a standard pulse oximeter in humans and demonstrated superior performance of the optoacoustic arterial oximeter, in particular at low blood flow.",
keywords = "Blood variables, High resolution, Noninvasive monitoring, Optoacoustics, Oxygenation, Ultrasound imaging",
author = "Petrov, {Irene Y.} and Yuriy Petrov and Donald Prough and Rinat Esenaliev",
year = "2011",
doi = "10.1117/12.879470",
language = "English (US)",
isbn = "9780819484369",
volume = "7899",
booktitle = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

}

TY - GEN

T1 - High-resolution ultrasound imaging and noninvasive optoacoustic monitoring of blood variables in peripheral blood vessels

AU - Petrov, Irene Y.

AU - Petrov, Yuriy

AU - Prough, Donald

AU - Esenaliev, Rinat

PY - 2011

Y1 - 2011

N2 - Ultrasound imaging is being widely used in clinics to obtain diagnostic information non-invasively and in real time. A high-resolution ultrasound imaging platform, Vevo (VisualSonics, Inc.) provides in vivo, real-time images with exceptional resolution (up to 30 microns) using high-frequency transducers (up to 80 MHz). Recently, we built optoacoustic systems for probing radial artery and peripheral veins that can be used for noninvasive monitoring of total hemoglobin concentration, oxyhemoglobin saturation, and concentration of important endogenous and exogenous chromophores (such as ICG). In this work we used the high-resolution ultrasound imaging system Vevo 770 for visualization of the radial artery and peripheral veins and acquired corresponding optoacoustic signals from them using the optoacoustic systems. Analysis of the optoacoustic data with a specially developed algorithm allowed for measurement of blood oxygenation in the blood vessels as well as for continuous, real-time monitoring of arterial and venous blood oxygenation. Our results indicate that: 1) the optoacoustic technique (unlike pure optical approaches and other noninvasive techniques) is capable of accurate peripheral venous oxygenation measurement; and 2) peripheral venous oxygenation is dependent on skin temperature and local hemodynamics. Moreover, we performed for the first time (to the best of our knowledge) a comparative study of optoacoustic arterial oximetry and a standard pulse oximeter in humans and demonstrated superior performance of the optoacoustic arterial oximeter, in particular at low blood flow.

AB - Ultrasound imaging is being widely used in clinics to obtain diagnostic information non-invasively and in real time. A high-resolution ultrasound imaging platform, Vevo (VisualSonics, Inc.) provides in vivo, real-time images with exceptional resolution (up to 30 microns) using high-frequency transducers (up to 80 MHz). Recently, we built optoacoustic systems for probing radial artery and peripheral veins that can be used for noninvasive monitoring of total hemoglobin concentration, oxyhemoglobin saturation, and concentration of important endogenous and exogenous chromophores (such as ICG). In this work we used the high-resolution ultrasound imaging system Vevo 770 for visualization of the radial artery and peripheral veins and acquired corresponding optoacoustic signals from them using the optoacoustic systems. Analysis of the optoacoustic data with a specially developed algorithm allowed for measurement of blood oxygenation in the blood vessels as well as for continuous, real-time monitoring of arterial and venous blood oxygenation. Our results indicate that: 1) the optoacoustic technique (unlike pure optical approaches and other noninvasive techniques) is capable of accurate peripheral venous oxygenation measurement; and 2) peripheral venous oxygenation is dependent on skin temperature and local hemodynamics. Moreover, we performed for the first time (to the best of our knowledge) a comparative study of optoacoustic arterial oximetry and a standard pulse oximeter in humans and demonstrated superior performance of the optoacoustic arterial oximeter, in particular at low blood flow.

KW - Blood variables

KW - High resolution

KW - Noninvasive monitoring

KW - Optoacoustics

KW - Oxygenation

KW - Ultrasound imaging

UR - http://www.scopus.com/inward/record.url?scp=79955507209&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79955507209&partnerID=8YFLogxK

U2 - 10.1117/12.879470

DO - 10.1117/12.879470

M3 - Conference contribution

AN - SCOPUS:79955507209

SN - 9780819484369

VL - 7899

BT - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

ER -