High risk human papillomavirus at entry to prenatal care and risk of preeclampsia

Mollie McDonnold, Holly Dunn, Ashley Hester, Luis Pacheco, Gary Hankins, George Saade, Maged Costantine

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Objective To determine the association between high-risk human papillomavirus (HR-HPV) and preeclampsia. Methods Retrospective cohort study of women with HR-HPV at entry to prenatal care compared with those with at least 2 normal pap smears. Preeclampsia was defined by clinical guidelines. Unadjusted and adjusted analyses were performed. Results Three hundred fourteen women with HR-HPV matched with 628 women with normal pap smears. Exposed HR-HPV patients were younger, had lower body mass index, systolic and diastolic blood pressure at entry to care, and more likely to be nulliparous and smokers. Exposed HR-HPV patients were more likely to develop preeclampsia (10.19% vs 4.94%; P =.004; adjusted odds ratio, 2.18; 95% confidence interval, 1.31-3.65). Women with HR-HPV were also more likely to deliver prematurely at less than 37 and less than 35 weeks. Conclusion HR-HPV is associated with an almost 2-fold increased risk of developing preeclampsia. This warrants a larger study, particularly when HPV infection can be prevented with vaccination.

Original languageEnglish (US)
JournalAmerican Journal of Obstetrics and Gynecology
Volume210
Issue number2
DOIs
StatePublished - Feb 2014

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Prenatal Care
Pre-Eclampsia
Papanicolaou Test
Blood Pressure
Vaccination
Body Mass Index
Cohort Studies
Retrospective Studies
Odds Ratio
Guidelines
Confidence Intervals
Infection

Keywords

  • human papilloma virus
  • preeclampsia

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

High risk human papillomavirus at entry to prenatal care and risk of preeclampsia. / McDonnold, Mollie; Dunn, Holly; Hester, Ashley; Pacheco, Luis; Hankins, Gary; Saade, George; Costantine, Maged.

In: American Journal of Obstetrics and Gynecology, Vol. 210, No. 2, 02.2014.

Research output: Contribution to journalArticle

McDonnold, Mollie ; Dunn, Holly ; Hester, Ashley ; Pacheco, Luis ; Hankins, Gary ; Saade, George ; Costantine, Maged. / High risk human papillomavirus at entry to prenatal care and risk of preeclampsia. In: American Journal of Obstetrics and Gynecology. 2014 ; Vol. 210, No. 2.
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