High sensitivity of in vivo detection of gold nanorods using a laser optoacoustic imaging system

Mohammad Eghtedari, Alexander Oraevsky, John A. Copland, Nicholas A. Kotov, Andre Conjusteau, Massoud Motamedi

Research output: Contribution to journalArticle

318 Citations (Scopus)

Abstract

The development of a contrast agent for a laser optoacoustic imaging system (LOIS) can significantly widen preclinical and clinical applications of this imaging modality for early detection of cancerous tumors. Gold nanorods were engineered to enhance the contrast for optoacoustic imaging. Under in vivo conditions, 25 μL of gold nanorods solution at a concentration of 1.25 pM were injected into nude mice and detected using a single-channel acoustic transducer. LOIS was used to visualize the distribution of gold nanoparticles at a concentration of 125 pM in vivo when 100 μL of solution of gold nanoparticles was delivered subcutaneously. Our results suggest that LOIS can be used for in vivo detection of gold nanorods at low concentrations and the nanoparticles can be engineered to enhance the diagnostic power of optoacoustic imaging.

Original languageEnglish (US)
Pages (from-to)1914-1918
Number of pages5
JournalNano Letters
Volume7
Issue number7
DOIs
StatePublished - Jul 2007

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Photoacoustic effect
Nanorods
Gold
Imaging systems
nanorods
gold
Lasers
sensitivity
lasers
Nanoparticles
Imaging techniques
nanoparticles
Acoustic transducers
Contrast Media
mice
Tumors
low concentrations
transducers
tumors
acoustics

ASJC Scopus subject areas

  • Materials Science(all)
  • Electronic, Optical and Magnetic Materials
  • Chemistry (miscellaneous)

Cite this

High sensitivity of in vivo detection of gold nanorods using a laser optoacoustic imaging system. / Eghtedari, Mohammad; Oraevsky, Alexander; Copland, John A.; Kotov, Nicholas A.; Conjusteau, Andre; Motamedi, Massoud.

In: Nano Letters, Vol. 7, No. 7, 07.2007, p. 1914-1918.

Research output: Contribution to journalArticle

Eghtedari, M, Oraevsky, A, Copland, JA, Kotov, NA, Conjusteau, A & Motamedi, M 2007, 'High sensitivity of in vivo detection of gold nanorods using a laser optoacoustic imaging system', Nano Letters, vol. 7, no. 7, pp. 1914-1918. https://doi.org/10.1021/nl070557d
Eghtedari, Mohammad ; Oraevsky, Alexander ; Copland, John A. ; Kotov, Nicholas A. ; Conjusteau, Andre ; Motamedi, Massoud. / High sensitivity of in vivo detection of gold nanorods using a laser optoacoustic imaging system. In: Nano Letters. 2007 ; Vol. 7, No. 7. pp. 1914-1918.
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