High sensitivity of in vivo detection of gold nanorods using a laser optoacoustic imaging system

Mohammad Eghtedari, Alexander Oraevsky, John A. Copland, Nicholas A. Kotov, Andre Conjusteau, Massoud Motamedi

    Research output: Contribution to journalArticlepeer-review

    344 Scopus citations

    Abstract

    The development of a contrast agent for a laser optoacoustic imaging system (LOIS) can significantly widen preclinical and clinical applications of this imaging modality for early detection of cancerous tumors. Gold nanorods were engineered to enhance the contrast for optoacoustic imaging. Under in vivo conditions, 25 μL of gold nanorods solution at a concentration of 1.25 pM were injected into nude mice and detected using a single-channel acoustic transducer. LOIS was used to visualize the distribution of gold nanoparticles at a concentration of 125 pM in vivo when 100 μL of solution of gold nanoparticles was delivered subcutaneously. Our results suggest that LOIS can be used for in vivo detection of gold nanorods at low concentrations and the nanoparticles can be engineered to enhance the diagnostic power of optoacoustic imaging.

    Original languageEnglish (US)
    Pages (from-to)1914-1918
    Number of pages5
    JournalNano Letters
    Volume7
    Issue number7
    DOIs
    StatePublished - Jul 2007

    ASJC Scopus subject areas

    • Bioengineering
    • Chemistry(all)
    • Materials Science(all)
    • Condensed Matter Physics
    • Mechanical Engineering

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