High-sensitivity troponin T in preterm infants with a hemodynamically significant patent ductus arteriosus

Priyanka Asrani, Ashraf Aly, Amyn Jiwani, Bruce R. Niebuhr, Robert H. Christenson, Sunil Jain

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: To investigate if a hemodynamically significant patent ductus arteriosus (hsPDA) leads to elevated high-sensitivity troponin T (hsTnT) and NTproBNP levels in serum. Study design: Infants <34 weeks and <1500 g were prospectively enrolled, except those with major congenital or chromosomal anomalies. An echocardiogram (ECHO) was performed and hsTnT and NTproBNP were measured within 5 days of life and repeated after treatment of hsPDA. Clinical, ECHO, and hsTnT data were analyzed using Student t-test, two proportion z-test, and regression analysis. Results: Seventy infants were enrolled. Infants in the hsPDA group had lower gestation and birth weight. Mean hsTnT and NTproBNP levels in the hsPDA group were higher compared to the group without an hsPDA, with levels being 251.54 vs 161.6 pg/ml, p < 0.01 for hsTnT and 18181.02 vs 3149.23 pg/ml, p < 0.001 for NTproBNP. Conclusion: HsPDA leads to increased hsTnT and NTproBNP levels in preterm infants without affecting cardiac function.

Original languageEnglish (US)
JournalJournal of Perinatology
DOIs
StateAccepted/In press - Jan 1 2018

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Troponin T
Patent Ductus Arteriosus
Premature Infants
Birth Weight
Regression Analysis
pro-brain natriuretic peptide (1-76)
Students
Pregnancy
Serum

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

High-sensitivity troponin T in preterm infants with a hemodynamically significant patent ductus arteriosus. / Asrani, Priyanka; Aly, Ashraf; Jiwani, Amyn; Niebuhr, Bruce R.; Christenson, Robert H.; Jain, Sunil.

In: Journal of Perinatology, 01.01.2018.

Research output: Contribution to journalArticle

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AU - Christenson, Robert H.

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